Recombinant Human Thioredoxin(TXN)

Manufacturer Cusabio
Category
Type Proteins
Specific against Human
Amount 200ug
Host E.coli
Item no. CSB-RP028144h-200
Eclass 6.1 34160400
Eclass 9.0 42020190
Available
Research areas
Transport
Target / Protein
TXN
Biologically active
Not Test
Species of origin
Homo sapiens (Human)
Uniprot ID
P10599
AA Sequence
VKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCK MIKPFFHSLSEKYSNVIFLEVDVDDCQDVASECEV KCMPTFQFFKKGQKVGEFSGANKEKLEATINELV
Tag info
N-terminal GST-tagged
Expression Region
2-105aa
Protein length
Full Length of Mature Protein
MW
38.6 kDa
Alternative Name(s)
ATL-derived factor ; ADFSurface-associated sulphydryl protein ; SASP
Relevance
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
Reference
Cloning and expression of a cDNA for human thioredoxin.Wollman E.E., D'Auriol L., Rimsky L., Shaw A., Jacquot J.-P., Wingfield P., Graber P., Dessarps F.J. Biol. Chem. 263:15506-15512(1988)
Purity
Greater than 90% as determined by SDS-PAGE.
Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Amount: 200ug
Available: In stock
Listprice: €546.07
Price: €546.07
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