Comparison

Recombinant Human D-3-phosphoglycerate dehydrogenase(PHGDH),partial

Manufacturer Cusabio
Category
Type Proteins Recombinant
Specific against other
Amount 200ug
Host E.coli
Item no. CSB-RP032554h-200
eClass 6.1 34160400
eClass 9.0 42020190
Available
Research Topic
Metabolism
Uniprot ID
O43175
Gene Names
PHGDH
Organism
Homo sapiens (Human)
AA Sequence
AFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNL SKEELIAELQDCEGLIVRSATKVTADVINAAEKLQ VVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSA AELTCGMIMCLARQIPQATASMKDGKWERKKFMGT ELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDP IISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLP STTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALL RALQS
Expression Region
2-251aa
Sequence Info
Partial
Source
E.coli
Tag Info
N-terminal GST-tagged
MW
53.8 kDa
Reference
Nucleotide sequence and differential expression of the human 3-phosphoglycerate dehydrogenase gene.Cho H.M., Jun D.Y., Bae M.A., Ahn J.D., Kim Y.H.Gene 245:193-201(2000)
Purity
Greater than 90% as determined by SDS-PAGE.
Storage Buffer
Tris-based buffer, 50% glycerol
Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function
Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.
Involvement in disease
Phosphoglycerate dehydrogenase deficiency (PHGDHD); Neu-Laxova syndrome 1 (NLS1)
Protein Families
D-isomer specific 2-hydroxyacid dehydrogenase family

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 200ug
Available: In stock
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