Recombinant Human Profilin-1(PFN1)

Manufacturer Cusabio
Category
Type Proteins
Specific against Human
Format Liquid
Amount 200ug
Host E.coli
ArtNr CSB-RP041544h-200
Eclass 6.1 34160400
Eclass 9.0 42020190
Available
Research areas
Neuroscience
Target / Protein
PFN1
Biologically active
Not Test
Species of origin
Homo sapiens (Human)
Uniprot ID
P07737
AA Sequence
AGWNAYIDNLMADGTCQDAAIVGYKDSPSVWAAVP GKTFVNITPAEVGVLVGKDRSSFYVNGLTLGGQKC SVIRDSLLQDGEFSMDLRTKSTGGAPTFNVTVTKT DKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY
Tag info
N-terminal GST-tagged
Expression Region
2-140aa
Protein length
Full Length of Mature Protein
MW
41.9 kDa
Alternative Name(s)
Epididymis tissue protein Li 184aProfilin I
Relevance
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
Reference
Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis.Kwiatkowski D.J., Bruns G.A.P.J. Biol. Chem. 263:5910-5915(1988)
Purity
Greater than 90% as determined by SDS-PAGE.
Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Amount: 200ug
Available: In stock
Listprice: €496.43
Price: €496.43
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