Recombinant Human Dr1-associated corepressor(DRAP1),partial

Manufacturer Cusabio
Category
Type Proteins
Specific against Human
Amount 200ug
Host E.coli
Item no. CSB-RP051444h-200
Eclass 6.1 34160400
Eclass 9.0 42020190
Available
Research Topic
Transcription
Uniprot ID
Q14919
Gene Names
DRAP1
Organism
Homo sapiens (Human)
AA Sequence
KKKKYNARFPPARIKKIMQTDEEIGKVAAAVPVII SRALELFLESLLKKACQVTQSRNAKTMTTSHLKQC IELEQQFDFLKDLVASVPDMQGDGEDNHMDGDKGA RRGRKPGSGGRKNGGMGTKSKDKKLSGTDSEQEDE SEDTDTDGEEETSQPPPQASHPSAHFQSPPTPFLP FASTLPLPPAPPGPSAPDEE
Expression Region
4-198aa
Sequence Info
Partial
Tag Info
N-terminal GST-tagged
MW
48.2 kDa
Alternative Name(s)
Dr1-associated protein 1Negative cofactor 2-alpha ; NC2-alpha
Relevance
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.
Reference
NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein.Klejman M.P., Pereira L.A., van Zeeburg H.J.T., Gilfillan S., Meisterernst M., Timmers H.T.M.Mol. Cell. Biol. 24:10072-10082(2004)
Purity
Greater than 90% as determined by SDS-PAGE.
Storage Buffer
Tris-based buffer, 50% glycerol
Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Amount: 200ug
Available: In stock
Listprice: €496.43
Price: €496.43
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