MOUSE ANTI HUMAN ACTH

GWB-42A22F

IgG1Species Cross Reactivity: Reacts with: RatN. B. Antibody reactivity and working conditions may vary between species.

Phosphate buffered saline pH7. 2

Synthetic peptide corresponding to the amino acids 1 - 24 of the human ACTH conjugated to Keyhole Limpet Haemocyanin.

ACTH stimulates the adrenal glands to release cortisol. MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes. Beta-endorphin and Met-enkephalin are endogenous opiates. Subcellular locationSecreted. Tissue specificityACTH and MSH are produced by the pituitary gland. Post-translational modificationSpecific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated; reducing sugar is probably N-acetylgalactosamine. Involvement in diseaseDefects in POMC may be associated with susceptibility to obesity [MIM:601665]. Defects in POMC are the cause of pro-opiomelanocortinin deficiency [MIM:609734]. Affected individuals present early-onset obesity adrenal insufficiency and red hair. Ref. 22Sequence similaritiesBelongs to the POMC family. 1. Willment et al. (2005) The human beta-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells. Eur. J. Immunol. 35: 1539-1547.