Antibodies

MOUSE ANTI HUMAN NEUROFILAMENT 160kDa

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against Human
Amount 0.1 mg
Host Mouse
ArtNr 20-783-314556
Available
Genway ID:
GWB-8502D1
Specificity:
NEUROFILAMENT 160kDa
Isotype:
IgG2a
Preparation:
Protein A chromatography
Buffer Solution:
PBS buffer pH 7. 2 10 mM Sodium Azide
Preservative Stabilisers:
See Buffer solution. Approx. Protein Concentrations: 2. 4 mg/ml
Immunogen:
Native
Specificity:
Tumours recognized include phaeochromocytoma paraganglioma ganglioneuroblastoma and other tumours of neuronal origin. Recommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGHuCAL Anti Mouse IgG2aRabbit Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgG IgA IgMGoat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L)
Function:
Neurofilaments usually contain three intermediate filament proteins: L M and H which are involved in the maintenance of neuronal caliber. Post-translational modificationThere are a number of repeats of the tripeptide K-S-P NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. Ref. 8Ref. 9Ref. 10Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H) the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function. Phosphorylated in the Head and Rod regions by the PKC kinase PKN1 leading to inhibit polymerization. Ref. 8Ref. 9Ref. 10Sequence similaritiesBelongs to the intermediate filament family.
Amount: 0.1 mg
Available: In stock
Listprice: €434.19
Price: €434.19
lieferbar

Get an offer

Technische Fragen zu diesem Produkt?


Salesmanager: Arne Pelz

Email: sales@hoelzel.de

Close