MOUSE ANTI HUMAN NEUROFILAMENT 160kDa

GWB-8502D1

IgG2a

PBS buffer pH 7. 2 10 mM Sodium Azide

Native

Neurofilaments usually contain three intermediate filament proteins: L M and H which are involved in the maintenance of neuronal caliber. Post-translational modificationThere are a number of repeats of the tripeptide K-S-P NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. Ref. 8Ref. 9Ref. 10Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H) the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function. Phosphorylated in the Head and Rod regions by the PKC kinase PKN1 leading to inhibit polymerization. Ref. 8Ref. 9Ref. 10Sequence similaritiesBelongs to the intermediate filament family.