MOUSE ANTI HUMAN CD279

CD279

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Detects CD279 a co-stimulatory molecule also known as programmed cell death-1 (PD-1). CD279 is 50-55kD membrane protein which is a member of the CD28 family and functions mainly as a negative regulator of T-cell activation. CD279 has two specific ligands; CD274 (PD-L1) and CD273 (PD-L2) and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance. CD279 is inducibly expressed by T-cells B-cells NK-T-cells and monocytes upon activation. Loss of CD279 function has been associated with a number of autoimmune diseases including rheumatoid arthritis type I diabetes and ankylosing spondylitis. Recent studies suggest that CD279 could be targeted therapeutically in the treatment of HIV infection to reduce T-cell exhaustion. Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROLRecommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgG IgA IgMHuCAL Anti Mouse IgG1Goat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L) [1] \" PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. \" Tang Y. T. Hu T. Arterburn M. Boyle B. Bright J. M. Emtage P. C. Funk W. D. J. Mol. Evol. 61:372-380(2005) [PubMed: 16044242] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] TISSUE SPECIFICITY. [2] \" Cloning and characterization of TESBP1A. \" Sugihara T. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. [3] \" Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. \" Lai C. -H. Chou C. -Y. Ch\' ang L. -Y. Liu C. -S. Lin W. -C. 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