MOUSE ANTI HUMAN ACTIVIN BetaC-SUBUNIT

GWB-3C04EE

IgG1Species Cross Reactivity: Reacts with: RatN. B. Antibody reactivity and working conditions may vary between species.

Is specific for the BetaC-subunit of Activin (BetaC-activin) a member of the transforming growth factor beta (TGF-beta) superfamily and one of a group of proteins which regulate growth and differentiation in a range of cells and tissues via both autocrine and paracrine pathways. Activins were originally characterised by the formation of specific homo- and heterodimers of activin BetaA- or BetaB-subunits but additional subunits of activin have since been identified including BetaC BetaD and BetaE. BetaC-activin expressed in the liver prostrate ovary and testis has been shown to exhibit both growth promoting and inhibitory properties and evidence suggests that BetaC-activin can form BetaC homodimers and also heterodimers with BetaA (putative activin AC) and BetaB (putative activin BC).

Inhibins and activins inhibit and activate respectively the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion gonadal hormone secretion germ cell development and maturation erythroid differentiation insulin secretion nerve cell survival embryonic axial development or bone growth depending on their subunit composition. Inhibins appear to oppose the functions of activins. Subunit structureHomodimeric or heterodimeric through association with alpha and beta subunits linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only By similarity. Subcellular locationSecreted By similarity. Tissue specificityExpressed in benign prostatic hyperplasia. Ref. 4Sequence similaritiesBelongs to the TGF-beta family.