Antibodies

MOUSE ANTI HUMAN CD86:FITC

Manufacturer GENWAY
Category
Type Antibody
Specific against Human
Amount 0.02 mg
Host Mouse
ArtNr 20-783-314903
Available
Genway ID:
GWB-B32334
Specificity:
CD86
Isotype:
IgG1
Preparation:
Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 2
Preservative Stabilisers:
0. 09% Sodium Azide 1% Bovine Serum AlbuminApprox. Protein Concentrations: IgG concentration 0. 1 mg/ml
Immunogen:
Human peripheral blood lymphocytes
Specificity:
Recognises the human CD86 antigen a cell surface protein expressed by activated B cells and monocytes. CD86 is also known as B7-2 and is the second ligand for CD28 and CTLA-4 and may have an important role in co-stimulation of T cells in the primary immune response. Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROL:FITC
Function:
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters and thus acts as a negative regulator of T-cell activation. Subunit structureInteracts with MARCH8. Interacts with human herpesvirus 8 MIR2 protein Probable. Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses. Ref. 11Ref. 12Subcellular locationMembrane; Single-pass type I membrane protein. Tissue specificityExpressed by activated B-lymphocytes and monocytes. Post-translational modificationPolyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation. Sequence similaritiesContains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Amount: 0.02 mg
Available: In stock
Listprice: €182.24
Discount: -10.0%
Price: €164.02
You save: €18.22
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