MOUSE ANTI HUMAN CD16

CD16

Purified IgG prepared by ion exchange chromatography

Recognises CD16 a 50-65kD cell surface molecule which exists in two forms - a transmembranous form expressed by NK cells and some T cells and a phosphatidylinositol linked form expressed by granulocytes. CD16 is a low affinity receptor for IgG (FcR III) and is an important receptor mediating ADCC by NK cells.

Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses such as phagocytosis. Subunit structureExists as a heterooligomeric receptor complex with Fc epsilon receptor I gamma subunit and / or the CD3 zeta subunit. Interacts with INPP5D/SHIP1 By similarity. Subcellular locationCell membrane; Single-pass type I membrane protein Potential. Secreted.

Encoded by one of two nearly indentical genes: FCGR3A (Shown here) and FCGR3B which are expressed in a tissue-specific manner. The Phe-203 in III-A determines the transmembrane domains whereas the \' Ser-203\' in III-B determines the GPI-anchoring. Sequence similaritiesContains 2 Ig-like C2-type (immunoglobulin-like) domains. Sequence cautionThe sequence BAD96988. 1 differs from that shown. Reason: Erroneous initiation. The sequence BAD97015. 1 differs from that shown. Reason: Erroneous initiation. 1. Bellingan. G. et al. (2002) Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation. J. Exp. Med. 196:1515-1521.