Antibodies

MOUSE ANTI HUMAN CD2

Manufacturer GENWAY
Category
Type Antibody
Specific against Human
Applications IP
Amount 0.02 mg
Host Mouse
ArtNr 20-783-314912
Available
Genway ID:
GWB-5D5F00
Specificity:
CD2
Isotype:
IgG2bSpecies Cross Reactivity: Reacts with: Rhesus MonkeyN. B. Antibody reactivity and working conditions may vary between species.
Preparation:
Purified IgG prepared by affinity chromatography on Protein A.
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium AzideApprox. Protein Concentrations: IgG concentration 1 mg/ml
Immunogen:
Normal human peripheral blood lymphocytes.
Specificity:
Is a single chain transmembrane glycoprotein of 50kD expressed by T cells NK cells and thymocytes. CD2 is a receptor for CD58 (LFA-3) and is important in mediating the interaction between T cells and target cells or antigen presenting cells.
Specificity:
Inhibits NK cell mediated cytotoxicity and ConA and PHA mediated blast transformation. Recommended Negative Controls: MOUSE IgG2b NEGATIVE CONTROLRecommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGRabbit Anti Mouse IgGGoat Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgGGoat Anti Mouse IgG IgA IgMRabbit Anti Mouse IgGHuCAL Anti Mouse IgG2bGoat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L)
Function:
CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells the cytoplasmic domain is implicated in the signaling function. Subunit structureInteracts with CD2AP By similarity. Interacts with PSTPIP1. Ref. 11Subcellular locationMembrane; Single-pass type I membrane protein. Sequence similaritiesContains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. 1. Bellingan. G. et al. (2002) Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation. J. Exp. Med. 196:1515-1521.
Amount: 0.02 mg
Available: In stock
Listprice: €152.38
Discount: -10.0%
Price: €137.14
You save: €15.24
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