Antibodies

MOUSE ANTI HUMAN CD4:Biotin

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against Human
Amount 0.02 mg
Host Mouse
ArtNr 20-783-314926
Available
Genway ID:
GWB-AFE20E
Specificity:
CD4
Isotype:
IgG1
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide 1% Bovine Serum AlbuminApprox. Protein Concentrations: IgG concentration 0. 1 mg/ml
Immunogen:
Human PHA blasts
Specificity:
Recognises human CD4 a 55kD cell surface glycoprotein that is primarily expressed on a subpopulation of T lymphocytes on peripheral blood monocytes and on tissue macrophages. Epitope mapping studies have shown that antibodies produced by clone RPA-T4 recognise an epitope within domain 1 of the extracellular region of the CD4 molecule. Clone RPA-T4 has been reported to block gp120-CD4 interaction and inhibit syncytium formation (2). Recommended Secondary Antibodies: STREPTAVIDIN
Function:
Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. Subunit structureAssociates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Ref. 15Ref. 18Ref. 19Ref. 21Subcellular locationCell membrane; Single-pass type I membrane protein.
Note:
Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with and sequesters CD4 in the endoplasmic reticulum. Ref. 20Post-translational modificationPalmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Miscellaneous:
Primary receptor for HIV-1. Sequence similaritiesContains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Amount: 0.02 mg
Available: In stock
Listprice: €212.88
Price: €212.88
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