Manufacturer GENWAY
Type Antibody
Specific against Mouse
Amount 0.1 mg
Host Rat
ArtNr 20-783-314589
Genway ID:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium AzideApprox. Protein Concentrations: IgG concentration 1. 0 mg/ml
T-cell enriched spleen cells from B10 mice
Recognises murine CD24 (also known as heat stable antigen) a 35-45kDa cell surface glycoprotein that is variably glycosylated. The M1/69 antigen is differentially expressed by developing haematopoietic cells including B-cells myeloid precursors thymocytes and erythroid cells. CD24 is not expressed by mouse peripheral T-cells and is a marker of haematopoietic differentiation in both B- and T-cell lineages. Clone M1/69 has been reported to agglutinate mouse red blood cells and to lyse mouse RBC\' s and thymocytes in the presence of complement (1). Recommended Negative Controls: RAT IgG2b NEGATIVE CONTROLRecommended Secondary Antibodies: Goat Anti Rat IgGRabbit Anti Rat IgGGoat Anti Rat IgG (MOUSE ADSORBED)
May have a specific role to play in early thymocyte development. Subcellular locationCell membrane; Lipid-anchor & rsaquo; GPI-anchor. Tissue specificityIn lymphoid myeloid and erythroid cells. Post-translational modificationThe identity of the N- and O-linked polysaccharides are not reported in Ref. 6. The O-linked polysaccharides on Ser-30 Ser-41 Ser-43 and Thr-51 are probably the mucin type linked to GalNAc. Sequence similaritiesBelongs to the CD24 family. [1] \" Identification of a novel FGF FGF-21 preferentially expressed in the liver. \" Nishimura T. Nakatake Y. Konishi M. Itoh N. Biochim. Biophys. Acta 1492:203-206(2000) [PubMed: 10858549] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [2] \" The secreted protein discovery initiative (SPDI) a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. \" Clark H. F. Gurney A. L. Abaya E. Baker K. Baldwin D. T. Brush J. Chen J. Chow B. Chui C. Crowley C. Currell B. Deuel B. Dowd P. Eaton D. Foster J. S. Grimaldi C. Gu Q. Hass P. E. Heldens S. Huang A. Kim H. S. Klimowski L. Jin Y. Johnson S. Lee J. Lewis L. Liao D. Mark M. R. Robbie E. Sanchez C. Schoenfeld J. Seshagiri S. Simmons L. Singh J. Smith V. Stinson J. Vagts A. Vandlen R. L. Watanabe C. Wieand D. Woods K. Xie M. -H. Yansura D. G. Yi S. Yu G. Yuan J. Zhang M. Zhang Z. Goddard A. D. Wood W. I. Godowski P. J. Gray A. M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. [3] NIEHS SNPs programSubmitted (JUL-2006) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] VARIANTS SER-141 AND PRO-174. [4] Mural R. J. Istrail S. Sutton G. G. Florea L. Halpern A. L. Mobarry C. M. Lippert R. Walenz B. Shatkay H. Dew I. Miller J. R. Flanigan M. J. Edwards N. J. Bolanos R. Fasulo D. Halldorsson B. V. Hannenhalli S. Turner R. Yooseph S. Lu F. Nusskern D. R. Shue B. C. Zheng X. H. Zhong F. Delcher A. L. Huson D. H. Kravitz S. A. Mouchard L. Reinert K. Remington K. A. Clark A. G. Waterman M. S. Eichler E. E. Adams M. D. Hunkapiller M. W. Myers E. W. Venter J. C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [5] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. [6] \" Signal peptide prediction based on analysis of experimentally verified cleavage sites. \" Zhang Z. Henzel W. J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]Cited for: PROTEIN SEQUENCE OF 29-43. [7] \" FGF-21 as a novel metabolic regulator. \" Kharitonenkov A. Shiyanova T. L. Koester A. Ford A. M. Micanovic R. Galbreath E. J. Sandusky G. E. Hammond L. J. Moyers J. S. Owens R. A. Gromada J. Brozinick J. T. Hawkins E. D. Wroblewski V. J. Li D. -S. Mehrbod F. Jaskunas S. R. Shanafelt A. B. J. Clin. Invest. 115:1627-1635(2005) [PubMed: 15902306] [Abstract]Cited for: FUNCTION. [8] \" Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. \" Kurosu H. Choi M. Ogawa Y. Dickson A. S. Goetz R. Eliseenkova A. V. Mohammadi M. Rosenblatt K. P. Kliewer S. A. Kuro-o M. J. Biol. Chem. 282:26687-26695(2007) [PubMed: 17623664] [Abstract]Cited for: FUNCTION. [9] \" C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors. \" Wu X. ||?||emon B. Li X. Gupte J. Weiszmann J. Stevens J. Hawkins N. Shen W. Lindberg R. Chen J. -L. Tian H. Li Y. J. Biol. Chem. 283:33304-33309(2008) [PubMed: 18829467] [Abstract]Cited for: INTERACTION WITH KLB. [10] \" Different roles of N- and C- termini in the functional activity of FGF21. \" Micanovic R. Raches D. W. Dunbar J. D. Driver D. A. Bina H. A. Dickinson C. D. Kharitonenkov A. J. Cell. Physiol. 219:227-234(2009) [PubMed: 19117008] [Abstract]Cited for: INTERACTION WITH KLB.
Amount: 0.1 mg
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