RAT ANTI MOUSE CD18:Biotin

Manufacturer GENWAY
Category
Type Antibody
Specific against Mouse
Amount 0.1 mg
Host Rat
ArtNr 20-783-314590
Available
Genway ID:
GWB-658D0B
Specificity:
CD18
Isotype:
IgG2a
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide 1% Bovine Serum AlbuminApprox. Protein Concentrations: IgG concentration 0. 1 mg/ml
Immunogen:
Membrane glycoproteins of cytotoxic T-cells
Specificity:
Recognises the murine beta 2 integrin (CD18). CD18 is a 95KD cell surface glycoprotein that forms heterodimers with the integrin subunit alpha L (CD11a) alpha M (CD11b) or alpha X (CD11c) to produce integrins CD11a/CD18 CD11b/CD18 and CD11c/CD18 respectively. CD18 is expressed by all leucocytes and plays an important role in adhesion and signalling in the haematopoietic system. Clone M18/2 has been reported to both inhibit and enhance certain functions of CD18 (please refer to references 2 and 3). Recommended Secondary Antibodies: STREPTAVIDIN
Function:
Integrin alpha-L/beta-2 is a receptor for ICAM1 ICAM2 ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Subunit structureHeterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L alpha-M alpha-X or alpha-D. Interacts with COPS5 and RANBP9 By similarity. Subcellular locationMembrane; Single-pass type I membrane protein. Sequence similaritiesBelongs to the integrin beta chain family. Contains 1 VWFA domain. [1] \" Molecular cloning and characterization of human frizzled-4 on chromosome 11q14-q21. \" Kirikoshi H. Sagara N. Koike J. Tanaka K. Sekihara H. Hirai M. Katoh M. Biochem. Biophys. Res. Commun. 264:955-961(1999) [PubMed: 10544037] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal lung. [2] \" cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www. cdna. org). \" Kopatz S. A. Aronstam R. S. Sharma S. V. Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart. [3] \" Complete sequencing and characterization of 21 243 full-length human cDNAs. \" Ota T. Suzuki Y. Nishikawa T. Otsuki T. Sugiyama T. Irie R. Wakamatsu A. Hayashi K. Sato H. Nagai K. Kimura K. Makita H. Sekine M. Obayashi M. Nishi T. Shibahara T. Tanaka T. Ishii S. Yamamoto J. Saito K. Kawai Y. Isono Y. Nakamura Y. Nagahari K. Murakami K. Yasuda T. Iwayanagi T. Wagatsuma M. Shiratori A. Sudo H. Hosoiri T. Kaku Y. Kodaira H. Kondo H. Sugawara M. Takahashi M. Kanda K. Yokoi T. Furuya T. Kikkawa E. Omura Y. Abe K. Kamihara K. Katsuta N. Sato K. Tanikawa M. Yamazaki M. Ninomiya K. Ishibashi T. Yamashita H. Murakawa K. Fujimori K. Tanai H. Kimata M. Watanabe M. Hiraoka S. Chiba Y. Ishida S. Ono Y. Takiguchi S. Watanabe S. Yosida M. Hotuta T. Kusano J. Kanehori K. Takahashi-Fujii A. Hara H. Tanase T. -O. Nomura Y. Togiya S. Komai F. Hara R. Takeuchi K. Arita M. Imose N. Musashino K. Yuuki H. Oshima A. Sasaki N. Aotsuka S. Yoshikawa Y. Matsunawa H. Ichihara T. Shiohata N. Sano S. Moriya S. Momiyama H. Satoh N. Takami S. Terashima Y. Suzuki O. Nakagawa S. Senoh A. Mizoguchi H. Goto Y. Shimizu F. Wakebe H. Hishigaki H. Watanabe T. Sugiyama A. Takemoto M. Kawakami B. Yamazaki M. Watanabe K. Kumagai A. Itakura S. Fukuzumi Y. Fujimori Y. Komiyama M. Tashiro H. Tanigami A. Fujiwara T. Ono T. Yamada K. Fujii Y. Ozaki K. Hirao M. Ohmori Y. Kawabata A. Hikiji T. Kobatake N. Inagaki H. Ikema Y. Okamoto S. Okitani R. Kawakami T. Noguchi S. Itoh T. Shigeta K. Senba T. Matsumura K. Nakajima Y. Mizuno T. Morinaga M. Sasaki M. Togashi T. Oyama M. Hata H. Watanabe M. Komatsu T. Mizush ma-Sugano J. Satoh T. Shirai Y. Takahashi Y. Nakagawa K. Okumura K. Nagase T. Nomura N. Kikuchi H. Masuho Y. Yamashita R. Nakai K. Yada T. Nakamura Y. Ohara O. Isogai T. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Trachea. [4] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. [5] \" A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. \" Tanaka S. Akiyoshi T. Mori M. Wands J. R. Sugimachi K. Proc. Natl. Acad. Sci. U. S. A. 95:10164-10169(1998) [PubMed: 9707618] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 257-318. Tissue: Oesophageal carcinoma. [6] \" Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy. \" Robitaille J. MacDonald M. L. E. Kaykas A. Sheldahl L. C. Zeisler J. Dube M. -P. Zhang L. -H. Singaraja R. R. Guernsey D. L. Zheng B. Siebert L. F. Hoskin-Mott A. Trese M. T. Pimstone S. N. Shastry B. S. Moon R. T. Hayden M. R. Goldberg Y. P. Samuels M. E. Nat. Genet. 32:326-330(2002) [PubMed: 12172548] [Abstract]Cited for: VARIANT EVR1 493-MET-TRP-494 DEL. [7] \" Vascular development in the retina and inner ear: control by Norrin and Frizzled-4 a high-affinity ligand-receptor pair. \" Xu Q. Wang Y. Dabdoub A. Smallwood P. M. Williams J. Woods C. Kelley M. W. Jiang L. Tasman W. Zhang K. Nathans J. Cell 116:883-895(2004) [PubMed: 15035989] [Abstract]Cited for: VARIANTS EVR1 VAL-105 AND VAL-157 CHARACTERIZATION OF VARIANTS EVR1 VAL-105; VAL-157 AND 493-MET-TRP-494 DEL. [8] \" The consensus coding sequences of human breast and colorectal cancers. \" Sjoeblom T. Jones S. Wood L. D. Parsons D. W. Lin J. Barber T. D. Mandelker D. Leary R. J. Ptak J. Silliman N. Szabo S. Buckhaults P. Farrell C. Meeh P. Markowitz S. D. Willis J. Dawson D. Willson J. K. V. Gazdar A. F. Hartigan J. Wu L. Liu C. Parmigiani G. Park B. H. Bachman K. E. Papadopoulos N. Vogelstein B. Kinzler K. W. Velculescu V. E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract]Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-436.
Amount: 0.1 mg
Available: In stock
Listprice: €332.39
Discount: -10.0%
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