Antibodies

RAT ANTI MOUSE TREM-1:FITC

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against Mouse
Amount 0.1 mg
Host Rat
ArtNr 20-783-314641
Available
Genway ID:
GWB-8ACA00
Specificity:
TREM-1
Isotype:
IgG2a
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide (NaN3) 1% Bovine Serum AlbuminApprox. Protein Concentrations: IgG concentration 0. 1mg/ml
Immunogen:
Mouse TREM-1 Fc fusion protein
Specificity:
Recognises mouse triggering receptor expressed on myeloid cells 1 (TREM-1) a 30kD member of the immunoglobulin superfamily expressed on neutrophils and a subset of monocytes. TREM-1 is involved in the microbial inflammatory response. It acts in conjunction with the adaptor protein DAP12 to activate neutrophils and monocytes leading to the secretion of pro-inflammatory mediators and enhancement of the inflammatory response. Microbial infection also induces the release of soluble form of TREM-1 from monocytes which is reported to act as an inhibitor of TREM-1. TREM-1 mediates the septic shock pathway and blocking TREM-1 has been reported to reduce inflammation and increase survival in certain models of bacterial infection. Recommended Negative Controls: RAT IgG2a NEGATIVE CONTROL:FITC
Function:
Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock By similarity. Subunit structureInteracts with TYROBP/DAP12 By similarity. Monomer. Ref. 3Subcellular locationMembrane; Single-pass type I membrane protein By similarity. Sequence similaritiesContains 1 Ig-like V-type (immunoglobulin-like) domain. [1] \" P110delta a novel phosphoinositide 3-kinase in leukocytes. \" Vanhaesebroeck B. A. M. Welham M. J. Kotani K. Stein R. Warne P. H. Zvelebil M. J. Higashi K. Volinia S. Downward J. Waterfield M. D. Proc. Natl. Acad. Sci. U. S. A. 94:4330-4335(1997) [PubMed: 9113989] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [2] Vanhaesebroeck B. A. M. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databasesCited for: SEQUENCE REVISION TO 675. [3] \" p110delta a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. \" Chantry D. Vojtek A. Kashishian A. Holtzman D. A. Wood C. Gray P. W. Cooper J. A. Hoekstra M. F. J. Biol. Chem. 272:19236-19241(1997) [PubMed: 9235916] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [4] \" Variations in the human phosphoinositide-3-kinase p110 gene in children with primary B-cell immunodeficiency of unknown etiology. \" Jou S. -T. Chien Y. -H. Yang Y. -H. Shyur S. -D. Chou C. -C. Chiang B. -L. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. [5] \" The DNA sequence and biological annotation of human chromosome 1. \" Gregory S. G. Barlow K. F. McLay K. E. Kaul R. Swarbreck D. Dunham A. Scott C. E. Howe K. L. Woodfine K. Spencer C. C. A. Jones M. C. Gillson C. Searle S. Zhou Y. Kokocinski F. McDonald L. Evans R. Phillips K. Atkinson A. Cooper R. Jones C. Hall R. E. Andrews T. D. Lloyd C. Ainscough R. Almeida J. P. Ambrose K. D. Anderson F. Andrew R. W. Ashwell R. I. S. Aubin K. Babbage A. K. Bagguley C. L. Bailey J. Beasley H. Bethel G. Bird C. P. Bray-Allen S. Brown J. Y. Brown A. J. Buckley D. Burton J. Bye J. Carder C. Chapman J. C. Clark S. Y. Clarke G. Clee C. Cobley V. Collier R. E. Corby N. Coville G. J. Davies J. Deadman R. Dunn M. Earthrowl M. Ellington A. G. Errington H. Frankish A. Frankland J. French L. Garner P. Garnett J. Gay L. Ghori M. R. J. Gibson R. Gilby L. M. Gillett W. Glithero R. J. Grafham D. V. Griffiths C. Griffiths-Jones S. Grocock R. Hammond S. Harrison E. S. I. Hart E. Haugen E. Heath P. D. Holmes S. Holt K. Howden P. J. Hunt A. R. Hunt S. E. Hunter G. Isherwood J. James R. Johnson C. Johnson D. Joy A. Kay M. Kershaw J. K. Kibukawa M. Kimberley A. M. King A. Knights A. J. Lad H. Laird G. Lawlor S. Leongamornlert D. A. Lloyd D. M. Loveland J. Lovell J. Lush M. J. Lyne R. Martin S. Mashreghi-Mohammadi M. Matthews L. Matthews N. S. W. McLaren S. Milne S. Mistry S. Moore M. J. F. Nickerson T. O\' Dell C. N. Oliver K. Palmeiri A. Palmer S. A. Parker A. Patel D. Pearce A. V. Peck A. I. Pelan S. Phelps K. Phillimore B. J. Plumb R. Rajan J. Raymond C. Rouse G. Saenphimmachak C. Sehra H. K. Sheridan E. Shownkeen R. Sims S. Skuce C. D. Smith M. Steward C. Subramanian S. Sycamore N. Tracey A. Tromans A. Van Helmond Z. Wall M. Wallis J. M. White S. Whitehead S. L. Wilkinson J. E. Willey D. L. Williams H. Wilming L. Wray P. W. Wu Z. Coulson A. Vaudin M. Sulston J. E. Durbin R. M. Hubbard T. Wooster R. Dunham I. Carter N. P. McVean G. Ross M. T. Harrow J. Olson M. V. Beck S. Rogers J. Bentley D. R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [6] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. [7] \" Autophosphorylation of p110 delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo. \" Vanhaesebroeck B. Higashi K. Raven C. Welham M. Anderson S. Brennan P. Ward S. G. Waterfield M. D. EMBO J. 18:1292-1302(1999) [PubMed: 10064595] [Abstract]Cited for: PROTEIN SEQUENCE OF 1031-1040 PHOSPHORYLATION AT SER-1039 MUTAGENESIS OF ARG-894 AND SER-1039. [8] \" Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. \" Rikova K. Guo A. Zeng Q. Possemato A. Yu J. Haack H. Nardone J. Lee K. Reeves C. Li Y. Hu Y. Tan Z. Stokes M. Sullivan L. Mitchell J. Wetzel R. Macneill J. Ren J. M. Yuan J. Bakalarski C. E. Villen J. Kornhauser J. M. Smith B. Li D. Zhou X. Gygi S. P. Gu T. -L. Polakiewicz R. D. Rush J. Comb M. J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract]Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-524 MASS SPECTROMETRY. Tissue: Lung carcinoma. [9] \" Large-scale proteomics analysis of the human kinome. \" Oppermann F. S. Gnad F. Olsen J. V. Hornberger R. Greff Z. Keri G. Mann M. Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract]Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-484; SER-520; TYR-524 AND SER-1039 MASS SPECTROMETRY.
Amount: 0.1 mg
Available: In stock
Listprice: €368.39
Price: €368.39
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