Antibodies

RAT ANTI MOUSE CD274

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against Mouse
Applications IP
Amount 0.1 mg
Host Rat
ArtNr 20-783-314653
Available
Genway ID:
GWB-9EAA6D
Specificity:
CD274
Isotype:
IgG2a
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide (NaN3)Approx. Protein Concentrations: IgG concentration 1. 0mg/ml
Immunogen:
Mouse CD274 - transfected L5178Y cells
Specificity:
Detects mouse CD274 also known as B7-H1 and PD-1L a cell surface glycoprotein which is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells and is induced on activated T-cells B-cells endothelial cells and epithelial cells in response to Interferons alpha beta and gamma. CD274 is reported to possess dual functions; inhibition of activated effector T cells and co-stimulation of naï ve T cells. CD274 inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. CD274 has also been shown to costimulate early T cell priming and differentiation. Deregulated CD274 function has been reported in chronic viral and intracellular bacterial infection as well as in many autoimmune diseases and cancers. Recommended Negative Controls: RAT IgG2a NEGATIVE CONTROLRecommended Secondary Antibodies: Goat Anti Rat IgGRabbit Anti Rat IgGGoat Anti Rat IgG (MOUSE ADSORBED)
Amount: 0.1 mg
Available: In stock
Listprice: €242.60
Price: €242.60
lieferbar

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