Comparison

RAT ANTI MOUSE CD274

Manufacturer GENWAY
Category
Type Antibody
Specific against Mouse
Applications IP
Amount 0.1 mg
Host Rat
Item no. 20-783-314653
eClass 6.1 32160702
eClass 9.0 32160702
Available
Genway ID:
GWB-9EAA6D
Specificity:
CD274
Isotype:
IgG2a
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide (NaN3)Approx. Protein Concentrations: IgG concentration 1. 0mg/ml
Immunogen:
Mouse CD274 - transfected L5178Y cells
Specificity:
Detects mouse CD274 also known as B7-H1 and PD-1L a cell surface glycoprotein which is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells and is induced on activated T-cells B-cells endothelial cells and epithelial cells in response to Interferons alpha beta and gamma. CD274 is reported to possess dual functions; inhibition of activated effector T cells and co-stimulation of naï ve T cells. CD274 inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. CD274 has also been shown to costimulate early T cell priming and differentiation. Deregulated CD274 function has been reported in chronic viral and intracellular bacterial infection as well as in many autoimmune diseases and cancers. Recommended Negative Controls: RAT IgG2a NEGATIVE CONTROLRecommended Secondary Antibodies: Goat Anti Rat IgGRabbit Anti Rat IgGGoat Anti Rat IgG (MOUSE ADSORBED)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 0.1 mg
Available: In stock
available

Delivery expected until 4/25/2024 

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