Antibodies

RAT ANTI MOUSE CD83:FITC

Manufacturer GENWAY
Category
Type Antibody
Specific against Mouse
Amount 0.1 mg
Host Rat
ArtNr 20-783-314719
Available
Genway ID:
GWB-A58C66
Specificity:
CD83
Isotype:
IgG2a
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide (NaN3) 1% Bovine Serum AlbuminApprox. Protein Concentrations: IgG concentration 0. 1mg/ml
Specificity:
Recognises murine CD83 a 45kD type 1 glyoprotein belonging to the immunoglobulin superfamily. Originally described as a maturation marker for dendritic cells CD83 plays a role in the regulation of antigen presentation thymic T-cell maturation B-cell function and peripheral T-cell activation. Activated dendritic cells and B-cells release a soluble form of CD83 that is reported to have an immunosuppressive effect suggesting a therapeutic role for sCD83 in the regulation of immune disorders. Recommended Negative Controls: RAT IgG2a NEGATIVE CONTROL:FITC
Function:
May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation By similarity. Subunit structureMonomer By similarity. Subcellular locationMembrane; Single-pass type I membrane protein By similarity. Tissue specificityAbundantly expressed in spleen and brain but is also detected in most tissues analyzed. Ref. 1Sequence similaritiesContains 1 Ig-like V-type (immunoglobulin-like) domain. [1] \" Human basic fibroblast growth factor: nucleotide sequence genomic organization and expression in mammalian cells. \" Abraham J. A. Whang J. L. Tumolo A. Mergia A. Fiddes J. C. Cold Spring Harb. Symp. Quant. Biol. 51:657-668(1986) [PubMed: 3472745] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [2] \" Human basic fibroblast growth factor: nucleotide sequence and genomic organization. \" Abraham J. A. Whang J. L. Tumolo A. Mergia A. Friedman J. Gospodarowicz D. Fiddes J. C. EMBO J. 5:2523-2528(1986) [PubMed: 3780670] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1). [3] \" High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons. \" Prats H. Kaghad M. Prats A. C. Klagsbrun M. Lelias J. M. Liauzun P. Chalon P. Tauber J. P. Amalric F. Smith J. A. Caput D. Proc. Natl. Acad. Sci. U. S. A. 86:1836-1840(1989) [PubMed: 2538817] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4) PROTEIN SEQUENCE OF 126-145 (ISOFORMS 1/2/4) ALTERNATIVE INITIATION. Tissue: Hepatoma. [4] \" Human protein factory for converting the transcriptome into an in vitro-expressed proteome. \" Goshima N. Kawamura Y. Fukumoto A. Miura A. Honma R. Satoh R. Wakamatsu A. Yamamoto J. Kimura K. Nishikawa T. Andoh T. Iida Y. Ishikawa K. Ito E. Kagawa N. Kaminaga C. Kanehori K. Kawakami B. Kenmochi K. Kimura R. Kobayashi M. Kuroita T. Kuwayama H. Maruyama Y. Matsuo K. Minami K. Mitsubori M. Mori M. Morishita R. Murase A. Nishikawa A. Nishikawa S. Okamoto T. Sakagami N. Sakamoto Y. Sasaki Y. Seki T. Sono S. Sugiyama A. Sumiya T. Takayama T. Takayama Y. Takeda H. Togashi T. Yahata K. Yamada H. Yanagisawa Y. Endo Y. Imamoto F. Kisu Y. Tanaka S. Isogai T. Imai J. Watanabe S. Nomura N. Nat. Methods 5:1011-1017(2008) [PubMed: 19054851] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). [5] NIEHS SNPs programSubmitted (MAR-2007) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [6] \" Generation and annotation of the DNA sequences of human chromosomes 2 and 4. \" Hillier L. W. Graves T. A. Fulton R. S. Fulton L. A. Pepin K. H. Minx P. Wagner-McPherson C. Layman D. Wylie K. Sekhon M. Becker M. C. Fewell G. A. Delehaunty K. D. Miner T. L. Nash W. E. Kremitzki C. Oddy L. Du H. Sun H. Bradshaw-Cordum H. Ali J. Carter J. Cordes M. Harris A. Isak A. van Brunt A. Nguyen C. Du F. Courtney L. Kalicki J. Ozersky P. Abbott S. Armstrong J. Belter E. A. Caruso L. Cedroni M. Cotton M. Davidson T. Desai A. Elliott G. Erb T. Fronick C. Gaige T. Haakenson W. Haglund K. Holmes A. Harkins R. Kim K. Kruchowski S. S. Strong C. M. Grewal N. Goyea E. Hou S. Levy A. Martinka S. Mead K. McLellan M. D. Meyer R. Randall-Maher J. Tomlinson C. Dauphin-Kohlberg S. Kozlowicz-Reilly A. Shah N. Swearengen-Shahid S. Snider J. Strong J. T. Thompson J. Yoakum M. Leonard S. Pearman C. Trani L. Radionenko M. Waligorski J. E. Wang C. Rock S. M. Tin-Wollam A. -M. Maupin R. Latreille P. Wendl M. C. Yang S. -P. Pohl C. Wallis J. W. Spieth J. Bieri T. A. Berkowicz N. Nelson J. O. Osborne J. Ding L. Meyer R. Sabo A. Shotland Y. Sinha P. Wohldmann P. E. Cook L. L. Hickenbotham M. T. Eldred J. Williams D. Jones T. A. She X. Ciccarelli F. D. Izaurralde E. Taylor J. Schmutz J. Myers R. M. Cox D. R. Huang X. McPherson J. D. Mardis E. R. Clifton S. W. Warren W. C. Chinwalla A. T. Eddy S. R. Marra M. A. Ovcharenko I. Furey T. S. Miller W. Eichler E. E. Bork P. Suyama M. Torrents D. Waterston R. H. Wilson R. K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [7] Mural R. J. Istrail S. Sutton G. G. Florea L. Halpern A. L. Mobarry C. M. Lippert R. Walenz B. Shatkay H. Dew I. Miller J. R. Flanigan M. J. Edwards N. J. Bolanos R. Fasulo D. Halldorsson B. V. Hannenhalli S. Turner R. Yooseph S. Lu F. Nusskern D. R. Shue B. C. Zheng X. H. Zhong F. Delcher A. L. Huson D. H. Kravitz S. A. Mouchard L. Reinert K. Remington K. A. Clark A. G. Waterman M. S. Eichler E. E. Adams M. D. Hunkapiller M. W. Myers E. W. Venter J. C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [8] \" Basic fibroblast growth factor gene expression. \" Florkiewicz R. Z. Shibata F. Barankiewicz T. Baird A. Gonzalez A. M. Florkiewicz E. Shah N. Ann. N. Y. Acad. Sci. 638:109-126(1991) [PubMed: 1785797] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-192. [9] \" Mutations in the 5\' untranslated region of the FGF-2 gene. \" Handschug K. Archoukieh E. Glaeser C. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-192. Tissue: Blood. [10] \" Cloning and expression of cDNA encoding human basic fibroblast growth factor. \" Kurokawa T. Sasada R. Iwane M. Igarashi K. FEBS Lett. 213:189-194(1987) [PubMed: 2435575] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-288 (ISOFORM 1).
Amount: 0.1 mg
Available: In stock
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