RAT ANTI MOUSE CD4

CD4

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Recognises mouse CD4 a 55 kDa protein also known as Ly-4 and L3T4. CD4 is a single chain transmembraneous glycoprotein which belongs to the immunoglobulin superfamily and is primarily expressed on peripheral blood monocytes and tissue macrophages. CD4 is also expressed on a subpopulation of regulatory T cells (CD4+ CD25+) which play a key role in the maintenance of self tolerance. Clone GK1. 5 has been reported to block CD4+ T-cell activation. It blocks class II MHC antigen-specific binding thereby inhibiting functions such as class II MHC antigen-specific proliferation and the release of lymphokines. It may also be used for in vivo and in vitro cell depletion of CD4+ T-cells. Recommended for functional assays. Recommended Negative Controls: RAT IgG2b NEGATIVE CONTROLRecommended Secondary Antibodies: Goat Anti Rat IgGRabbit Anti Rat IgGGoat Anti Rat IgG (MOUSE ADSORBED)