Antibodies

RAT ANTI MOUSE CD45:FITC

Manufacturer GENWAY
Category
Type Antibody
Specific against Mouse
Amount 0.02 mg
Host Rat
ArtNr 20-783-314886
Available
Genway ID:
GWB-3A4257
Specificity:
CD45
Isotype:
IgG2b
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline
Preservative Stabilisers:
0. 09% Sodium Azide 1% Bovine Serum AlbuminApprox. Protein Concentrations: IgG concentration 0. 1 mg/ml
Immunogen:
Mouse spleen cells.
Specificity:
Recognises the murine CD45 cell surface antigen a 180-220kD glycoprotein expressed by all leucocytes. N. B. Some reactivity with human tissue has been observed. Recommended Negative Controls: RAT IgG2b NEGATIVE CONTROL:FITC
Function:
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation recruits and dephosphorylates SKAP1 and FYN By similarity. Catalytic activityProtein tyrosine phosphate + H2O = protein tyrosine + phosphate. Subunit structureInteracts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes By similarity. Binds GANAB and PRKCSH. Ref. 12Subcellular locationMembrane; Single-pass type I membrane protein. Membrane raft By similarity.
Note:
Colocalized with DPP4 in membrane rafts By similarity. Developmental stageExpression is restricted to the hematopoietic compartment of development.
Domain:
The first PTPase domain interacts with SKAP1 By similarity. Post-translational modificationHeavily N- and O-glycosylated. Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. Contains 2 fibronectin type-III domains. Contains 2 tyrosine-protein phosphatase domains. Sequence cautionThe sequence AAA39460. 1 differs from that shown. Reason: Erroneous initiation. The sequence AAA39462. 1 differs from that shown. Reason: Erroneous initiation.
Amount: 0.02 mg
Available: In stock
Listprice: €182.24
Discount: -10.0%
Price: €164.02
You save: €18.22
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