Antibodies

RAT ANTI MOUSE CD45

Manufacturer GENWAY
Category
Type Antibody
Specific against Mouse
Applications IP
Amount 0.02 mg
Host Rat
ArtNr 20-783-314887
Available
Genway ID:
GWB-7AF3DF
Specificity:
CD45
Isotype:
IgG2b
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium AzideApprox. Protein Concentrations: IgG concentration 1. 0 mg/ml
Immunogen:
Mouse spleen cells.
Specificity:
Recognises the murine CD45 cell surface antigen a 180-220kD glycoprotein expressed by all leucocytes. N. B. Some reactivity with human tissue has been observed. Recommended Negative Controls: RAT IgG2b NEGATIVE CONTROLRecommended Secondary Antibodies: Goat Anti Rat IgGRabbit Anti Rat IgGGoat Anti Rat IgG (MOUSE ADSORBED)
Function:
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation recruits and dephosphorylates SKAP1 and FYN By similarity. Catalytic activityProtein tyrosine phosphate + H2O = protein tyrosine + phosphate. Subunit structureInteracts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes By similarity. Binds GANAB and PRKCSH. Ref. 12Subcellular locationMembrane; Single-pass type I membrane protein. Membrane raft By similarity.
Note:
Colocalized with DPP4 in membrane rafts By similarity. Developmental stageExpression is restricted to the hematopoietic compartment of development.
Domain:
The first PTPase domain interacts with SKAP1 By similarity. Post-translational modificationHeavily N- and O-glycosylated. Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. Contains 2 fibronectin type-III domains. Contains 2 tyrosine-protein phosphatase domains. Sequence cautionThe sequence AAA39460. 1 differs from that shown. Reason: Erroneous initiation. The sequence AAA39462. 1 differs from that shown. Reason: Erroneous initiation.
Amount: 0.02 mg
Available: In stock
Listprice: €152.38
Discount: -10.0%
Price: €137.14
You save: €15.24
lieferbar

Get an offer

Technische Fragen zu diesem Produkt?


Salesmanager: Arne Pelz

Email: sales@hoelzel.de

Close