Antibodies

RAT ANTI MOUSE CD8

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against Mouse
Amount 0.02 mg
Host Rat
ArtNr 20-783-314900
Available
Genway ID:
GWB-827925
Specificity:
CD8 ALPHA
Isotype:
IgG2a
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium AzideApprox. Protein Concentrations: IgG concentration 1 mg/ml
Immunogen:
Mouse spleen cells
Specificity:
Recognises a non polymorphic epitope on the mouse CD8 alpha chain. Blocks MHC I dependent T cell responses in vitro and in vivo and induces transplantation tolerance in combination with CD4 antibodies. Recommended Negative Controls: RAT IgG2a NEGATIVE CONTROLRecommended Secondary Antibodies: Goat Anti Rat IgGRabbit Anti Rat IgGGoat Anti Rat IgG (MOUSE ADSORBED)
Function:
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. Subunit structureIn general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Subcellular locationMembrane; Single-pass type I membrane protein. Sequence similaritiesContains 1 Ig-like V-type (immunoglobulin-like) domain.
Amount: 0.02 mg
Available: In stock
Listprice: €152.38
Price: €152.38
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