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RAT ANTI MOUSE CD8

RAT ANTI MOUSE CD8

Manufacturer	GENWAY
Category	Oncology Antibodies By Cell Type Hematology Leukemia Primary Antibodies
Type	Antibody
Specific against	Mouse
Amount	25 ug
Host	Rat
Item no.	20-783-314900
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-827925
Specificity:	CD8 ALPHA
Isotype:	IgG2a
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09% Sodium AzideApprox. Protein Concentrations: IgG concentration 1 mg/ml
Immunogen:	Mouse spleen cells
Specificity:	Recognises a non polymorphic epitope on the mouse CD8 alpha chain. Blocks MHC I dependent T cell responses in vitro and in vivo and induces transplantation tolerance in combination with CD4 antibodies. Recommended Negative Controls: RAT IgG2a NEGATIVE CONTROLRecommended Secondary Antibodies: Goat Anti Rat IgGRabbit Anti Rat IgGGoat Anti Rat IgG (MOUSE ADSORBED)
Function:	Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. Subunit structureIn general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Subcellular locationMembrane; Single-pass type I membrane protein. Sequence similaritiesContains 1 Ig-like V-type (immunoglobulin-like) domain.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25 ug

available

Delivery expected until 5/30/2024