CD44


Manufacturer	GENWAY
Category	Oncology Antibodies Flow Cytometry Immunoprecipitation Primary Antibodies By Organ Gastric Cancer
Type	Antibody
Specific against	other
Clone	5035-41. 1D
Applications	FC, IP
Amount	0.025 mg
Item no.	20-783-310006
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-B04E30
Specificity:	CD44
Specificity:	CD44
Clone:	5035-41. 1D
Immunogen:	Spleen cells from B6PL-Ly-2a / Ly-3a B6-Ly-1a mice
Fusion Partner:	Spleen cells from immunised mice were fused with cells of the mouse P3-NS1-1-Ag4 myeloma cell line.
Specificity Note:	Ly24. 2 found on > 90% bone marrow cells and spleen cells 56% of thymus cells and 90% of lymph node cells. This antibody recognises the following strains of mice:- C57BL/6 C57BL/10 C57/L C58A AKR 129 SJL NZB C3H CE CBA/H.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells or 100ul whole bloodSuggested
Dilution:	Flow Cytometry - 1:50 - 1:100
Function:	Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA and possibly also through its affinity for other ligands such as osteopontin collagens and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration tumor growth and progression. Also involved in lymphocyte activation recirculation and homing and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
Subunit:	Interacts with HA as well as other glycosaminoglycans collagen laminin and fibronectin via its N-terminal segment. Interacts with ANK the ERM proteins (VIL2 RDX and MSN) and NF2 via its C-terminal segment.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	An epithelial isoform (CD44E) is expressed by cells of epithelium and highly expressed by carcinomas. An hematopoietic isoform (CD44H) is expressed by cells of mesodermal origin. Expression is repressed in neuroblastoma cells.
Ptm:	Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.
Ptm:	N-glycosylated.
Ptm:	O-glycosylated; contains more-or-less-sulfated chondroitin sulfate glycans whose number may affect the accessibility of specific proteinases to their cleavage site(s).
Ptm:	Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site) and the phosphorylation of Ser-672.
Polymorphism:	CD44 is responsible for the Indian blood group system. The molecular basis of the In(A)=In1/In(B)=In2 blood group antigens is a single variation in position 46; In(B) the most frequent allele has Arg-46.
Similarity:	Contains 1 Link domain. 1. Sutton. V. R. et al. (1987) Genetic and biochemical characterization of antigens encoded by the Ly24 (Pgp-1) locus.

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Amount: 0.025 mg

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Delivery expected until 5/30/2024