Manufacturer |
GENWAY
|
Category |
|
Type |
Antibody |
Specific against |
other |
Clone |
DF1513 |
Applications |
FC |
Amount |
0.025 mg |
Item no. |
20-783-310027 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Genway ID: |
GWB-8E4B13 |
Specificity: |
CD71 NCBI |
Gene ID: |
7037 |
Specificity: |
CD71 |
Clone: |
DF1513 |
Preparation: |
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant. |
Buffer Solution: |
Phosphate buffered saline pH7. 4 |
|
Preservative Stabilisers: |
| 0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested |
Flow Cytometry: |
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested |
Dilution: |
Flow Cytometry - Neat |
Function: |
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand the heditary hemochromatosis protein HFE competes for binding with transferrin for an overlapping C-terminal binding site. |
Subunit: |
Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen DR1. Interacts with SH3BP3. |
Subcellular Location: |
Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
Subcellular Location: |
Transferrin receptor protein 1 serum form: Secreted. |
Induction: |
Regulated by cellular iron levels through binding of the iron regulatory proteins IRP1 and IRP2 to iron-responsive elements in the 3\' -UTR. Up-regulated upon mitogenic stimulation. |
Ptm: |
N- and O-glycosylated phosphorylated and palmitoylated. The serum form is only glycosylated. |
Ptm: |
Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR). |
Ptm: |
Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation. |
Miscellaneous: |
Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemia resulting from a number of conditions including rheumatoid arthritis pregnancy irritable bowel syndrome and in HIV patients. |
Miscellaneous: |
Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells. |
Similarity: |
Belongs to the peptidase M28 family. M28B subfamily [view classification]. |
Similarity: |
Contains 1 PA (protease associated) domain. 1. Sopper. E. et al. (1997) Lymphocyte subsets and expression of differentiation markers in blood and lymphoid organs of rhesus monkeys. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
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