CD49d


Manufacturer	GENWAY
Category	Oncology Neuroscience Neural Adhesion Molecules Antibodies Cell Biology Cell Movement Cell Adhesion Flow Cytometry Primary Antibodies By Organ Bone Cancer
Type	Antibody
Specific against	other
Clone	PS/2
Applications	FC
Amount	25 TESTS
Item no.	20-783-310034
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-FCCE0B
Specificity:	CD49dNCBI
Gene ID:	16401
Specificity:	CD49d
Clone:	PS/2
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum Albumin Reconstitution: Reconstitute in 0. 25 ml disilled waterSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Dilution:	Flow Cytometry - Neat - 1/10
Function:	Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
Subunit:	Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN LPXN and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Domain:	The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.
Ptm:	Phosphorylation on Ser-1027 inhibits PXN binding.
Similarity:	Belongs to the integrin alpha chain family.
Similarity:	Contains 7 FG-GAP repeats. 1. Miyake. K. et al. (1991) Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis. 2. Miyake. K. et al. (1991) A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture. 3. Andrew. D. P. et al. (1994) Distinct but Overlapping Epitopes Are Involved in alpha4 beta7-Mediated Adhesion to Vascular Cell Adhesion Molecule-1. Mucosal Addressin-1. Fibronectin. and Lymphocyte Aggregation.

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Amount: 25 TESTS

available

Delivery expected until 5/9/2024