CD45R

CD45RNCBI

CD45R

Purified IgG prepared by affinity chromatography on Protein G

Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested

Required for T-cell activation through the antigen receptor. The first PTPase domain has enzymatic activity while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation recruits an dephosphorylates SKAP1 and FYN.

Binds GANAB and PRKCSH (By similarity). Interacts with SKAP1.

The first PTPase domain interacts with SKAP1.

Defects in PTPRC are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+)SCID) [MIM:608971]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity leukopenia and low or absent antibody levels. Patients with SCID present in infancy with recurrent persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.

Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.

Contains 2 tyrosine-protein phosphatase domains. 1. Spangrude. G. J. et al. (1988) Purification and characterization of mouse hematopoietic stem cells. 2. Coffman. R. (1982) Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development. 3. Rosmalen. J. G. M. et al. (2000) Subsets of macrophages and dendritic cells in nonobese diabetic mouse pancreatic inflammatory infiltrates: correlation with the development of diabetes. 4. Spangrude. G. J. et al. (1988) Two rare populations of mouse Thy-1lo bone marrow cells repopulate the thymus. 5. Holmes. K. L. et al. (1986) Analysis of neoplasms induced by Cas-Br-M MuLV tumor extracts. 6. Whiteland. J. L. et al. (1995) Immunohistochemical detection of T-Cell subsets and other leucocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies. J. Histochem. Cytochem. 43: 313-320. 7. Monteith. C. E. et al. (1996) Identification of monoclonal antibodies for immunohistochemical staining of feline B lymphocytes in frozen and formalin fixed paraffin embedded tissues.