Antibodies

CD45R

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against other
Clone RA3-6B2
Applications FC
Amount 25 TESTS
ArtNr 20-783-310039
Available
Genway ID:
GWB-784C4B
Specificity:
CD45RNCBI
Gene ID:
19264
Specificity:
CD45R
Clone:
RA3-6B2
Preparation:
Purified IgG prepared by affinity chromatography on Protein G
Preservative Stabilisers:
0. 09%Sodium Azide1%Bovine Serum Albumin
Reconstitution: Reconstitute with 0. 25 ml distilled water Suggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Dilution:
Flow Cytometry - Neat
Function:
Required for T-cell activation through the antigen receptor. The first PTPase domain has enzymatic activity while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation recruits an dephosphorylates SKAP1 and FYN.
Catalytic Activity:
Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subunit:
Binds GANAB and PRKCSH (By similarity). Interacts with SKAP1.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Domain:
The first PTPase domain interacts with SKAP1.
Ptm:
Heavily N- and O-glycosylated.
Disease:
Defects in PTPRC are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+)SCID) [MIM:608971]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity leukopenia and low or absent antibody levels. Patients with SCID present in infancy with recurrent persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
Disease:
Genetic variations in PTPRC are involved in multiple sclerosis susceptibility (MS) [MIM:126200]. MS is a neurodegenerative disorder characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in third or fourth decade with intermittent progression over an extended period. The cause is still uncertain.
Similarity:
Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
Similarity:
Contains 2 fibronectin type-III domains.
Similarity:
Contains 2 tyrosine-protein phosphatase domains. 1. Spangrude. G. J. et al. (1988) Purification and characterization of mouse hematopoietic stem cells. 2. Coffman. R. (1982) Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development. 3. Rosmalen. J. G. M. et al. (2000) Subsets of macrophages and dendritic cells in nonobese diabetic mouse pancreatic inflammatory infiltrates: correlation with the development of diabetes. 4. Spangrude. G. J. et al. (1988) Two rare populations of mouse Thy-1lo bone marrow cells repopulate the thymus. 5. Holmes. K. L. et al. (1986) Analysis of neoplasms induced by Cas-Br-M MuLV tumor extracts. 6. Whiteland. J. L. et al. (1995) Immunohistochemical detection of T-Cell subsets and other leucocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies. J. Histochem. Cytochem. 43: 313-320. 7. Monteith. C. E. et al. (1996) Identification of monoclonal antibodies for immunohistochemical staining of feline B lymphocytes in frozen and formalin fixed paraffin embedded tissues.
Amount: 25 TESTS
Available: In stock
Listprice: €212.88
Price: €212.88
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