CD62L

GWB-7B3CBC

20343

MEL-14

Spleen cells from immunised Fischer rats were fused with cells of the mouse P3. X63. Ag8. 653 myeloma cell line.

Flow Cytometry - 1ug/ml

Interaction with PSGL1/SELPLG is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan and tyrosine sulfation modifications of PSGL1. Sulfation on Y-51 of PSGL1 is important for L-selectin binding.

Expressed in B cell lines and T lymphocytes.

Contains 1 C-type lectin domain.

Contains 2 Sushi (CCP/SCR) domains. 1. Fink. P. et al. (1985) Homing receptor-bearing thymocytes. an immunocompetent cortical subpopulation 2. Gallatin. W. M. et al. (1983) A cell surface molecule involved in organ specific homing of lymphocytes. 3. Lewinsohn. D. M. et al. (1987) Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils. lymphocytes. and other leukocytes. 4. Reichert. R. M. et al. (1984) A homing receptor-bearing cortical thymocyte subset: Implications for thymus cell migration and the nature of cortisone-resistant thymocytes. 5. Siegleman. M. et al. (1990) The mouse lymph node homing receptor is identical with the lymphocyte cell surface marker Ly-22: role of the EGF domain in endothelial binding 6. Jalkanen. S. et al. (1987) Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85-95-kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node. mucosal. or synovial endothelial cells.