CD62L

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone MEL-14
Applications FC, IP, IHC
Amount 0.025 mg
ArtNr 20-783-310040
Available
Genway ID:
GWB-7B3CBC
Specificity:
CD62LNCBI
Gene ID:
20343
Specificity:
CD62L
Clone:
MEL-14
Immunogen:
Mouse B cell lymphoma 38C-14
Fusion Partner:
Spleen cells from immunised Fischer rats were fused with cells of the mouse P3. X63. Ag8. 653 myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G.
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:
Flow Cytometry - 1ug/ml
Function:
Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
Subunit:
Interaction with PSGL1/SELPLG is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan and tyrosine sulfation modifications of PSGL1. Sulfation on Y-51 of PSGL1 is important for L-selectin binding.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Expressed in B cell lines and T lymphocytes.
Similarity:
Belongs to the selectin/LECAM family.
Similarity:
Contains 1 C-type lectin domain.
Similarity:
Contains 1 EGF-like domain.
Similarity:
Contains 2 Sushi (CCP/SCR) domains. 1. Fink. P. et al. (1985) Homing receptor-bearing thymocytes. an immunocompetent cortical subpopulation 2. Gallatin. W. M. et al. (1983) A cell surface molecule involved in organ specific homing of lymphocytes. 3. Lewinsohn. D. M. et al. (1987) Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils. lymphocytes. and other leukocytes. 4. Reichert. R. M. et al. (1984) A homing receptor-bearing cortical thymocyte subset: Implications for thymus cell migration and the nature of cortisone-resistant thymocytes. 5. Siegleman. M. et al. (1990) The mouse lymph node homing receptor is identical with the lymphocyte cell surface marker Ly-22: role of the EGF domain in endothelial binding 6. Jalkanen. S. et al. (1987) Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85-95-kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node. mucosal. or synovial endothelial cells.
Amount: 0.025 mg
Available: In stock
Listprice: €152.38
Discount: -10.0%
Price: €137.14
You save: €15.24
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