CD11a


Manufacturer	GENWAY
Category	Oncology Antibodies Flow Cytometry Primary Antibodies By Organ Skin Cancer
Type	Antibody
Specific against	other
Clone	I21/7
Applications	FC
Amount	25 TESTS
Item no.	20-783-310066
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-CC78DE
Specificity:	CD11aNCBI
Gene ID:	16408
Specificity:	CD11a
Clone:	I21/7
Immunogen:	Whole BW5147 cells
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum Albumin Reconstitution: Reconstitute in 0. 25 ml disilled waterSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Dilution:	Flow Cytometry - Neat - 1/2
Function:	Integrin alpha-L/beta-2 is a receptor for ICAM1 ICAM2 ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction cytotoxic T-cell mediated killing and antibody dependent killing by granulocytes and monocytes.
Subunit:	Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Leukocytes.
Domain:	The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Similarity:	Belongs to the integrin alpha chain family.
Similarity:	Contains 7 FG-GAP repeats.
Similarity:	Contains 1 VWFA domain. 1. Trowbridge. I. S. and Omary. M. B. (1981) Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen MAC-1. 2. Champe. M. et al. (1995) Monoclonal Antibodies That Block the Activity of Leukocyte Function-associated Antigen-1 Recognize Three Discrete Epitopes in the Inserted Domain of CD11a. 3. Springer. T. et al. (1982) LFA-1 and Lyt-2. 3. molecules associated with T lymphocyte-mediated killing; and Mac-1. an LFA-1 homologue associated with complement receptor function 4. Falanga. P. B. and Butcher E. C. (1991) Late treatment with anti-LFA-1 (CD11a) antibody prevents cerebral malaria in a mouse model. 5. Campbell. S. B. et al. (2001) CD4 ligation promotes the IL-4-independent development of IL-4-producing clones from naive CD4(+) T cells 6. Talento. A. et al. (1993) A single administration of LFA-1 antibody confers prolonged allograft survival. 7. Barret. T. B. et al. (1991) CD40 signaling activates CD11a/CD18 (LFA-1)-mediated adhesion in B cells.

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Amount: 25 TESTS

available

Delivery expected until 5/9/2024