CD19


Manufacturer	GENWAY
Category	Oncology Antibodies Flow Cytometry Primary Antibodies By Organ Lung Cancer
Type	Antibody
Specific against	other
Clone	6D5
Applications	FC
Amount	0.025 mg
Item no.	20-783-310091
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-AC1947
Specificity:	CD19NCBI
Gene ID:	12478
Specificity:	CD19
Clone:	6D5
Immunogen:	Human K562 cell line transfected with murine CD19
Fusion Partner:	Spleen cells from immunised rats were fused with cells of the P3X63. Ag8. 653 myeloma cell line.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Dilution:	Flow Cytometry - Neat
Function:	Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
Subunit:	Forms a complex with CD21 CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Ptm:	Phosphorylated on serine and threonine upon DNA damage probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation.
Disease:	Defects in CD19 are a cause of hypogammaglobulinemia [MIM:107265].
Similarity:	Contains 2 Ig-like C2-type (immunoglobulin-like) domains. 1. Krop. I. et al. (1996) Self-renewal of B-1 lymphocytes is dependent on CD19 2. Vernooy. J. et al. (2002) Long-term intratracheal lipopolysaccharide exposure in mice results in chronic lung inflammation and persistent pathology.

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Amount: 0.025 mg

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Delivery expected until 5/9/2024