CD19

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone 6D5
Applications FC
Amount 0.025 mg
ArtNr 20-783-310091
Available
Genway ID:
GWB-AC1947
Specificity:
CD19NCBI
Gene ID:
12478
Specificity:
CD19
Clone:
6D5
Immunogen:
Human K562 cell line transfected with murine CD19
Fusion Partner:
Spleen cells from immunised rats were fused with cells of the P3X63. Ag8. 653 myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Dilution:
Flow Cytometry - Neat
Function:
Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
Subunit:
Forms a complex with CD21 CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Ptm:
Phosphorylated on serine and threonine upon DNA damage probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation.
Disease:
Defects in CD19 are a cause of hypogammaglobulinemia [MIM:107265].
Similarity:
Contains 2 Ig-like C2-type (immunoglobulin-like) domains. 1. Krop. I. et al. (1996) Self-renewal of B-1 lymphocytes is dependent on CD19 2. Vernooy. J. et al. (2002) Long-term intratracheal lipopolysaccharide exposure in mice results in chronic lung inflammation and persistent pathology.
Amount: 0.025 mg
Available: In stock
Listprice: €168.20
Discount: -10.0%
Price: €151.38
You save: €16.82
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