CD119

GWB-E2DE40

3459

BB1E2

Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0-Ag14 myeloma cell line.

Purified IgG prepared by ion exchange chromatography

Flow Cytometry - 1ug/ml - 10ug/mlImmunohistology - Frozen - 1ug/ml - 10ug/mlELISA - 1ug/mlWestern Blotting - 1ug/ml

Monomer.

Phosphorylated at Ser/Thr residues.

Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood whereas others develop later in life disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive autosomal dominant or X-linked inheritance.

Contains 2 fibronectin type-III domains.