CD119

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone BB1E2
Applications WB, FC, IHC, ELISA
Amount 0.025 mg
ArtNr 20-783-310097
Available
Genway ID:
GWB-E2DE40
Specificity:
CD119NCBI
Gene ID:
3459
Specificity:
CD119
Clone:
BB1E2
Immunogen:
Fusion protein of the extracellular part of the human interferon-gamma receptor (AA: Ala17-Gly245) to 11 AA of the c-myc proto-oncogene (for affinity purification).
Fusion Partner:
Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0-Ag14 myeloma cell line.
Specificity Note:
In Western Blotting only one protein band is stained corresponding to a MW of 43 000 which is equal to the MW for the glycosylated extracellular part of the human extra-cellular interferon-gamma receptor (fused to c-myc) and a MW of 27 000 corresponding to the non-glycosylated part (fused to c-myc). The antibody does not neutralise biological activity of interferon gamma.
Preparation:
Purified IgG prepared by ion exchange chromatography
Buffer Solution:
Phosphate buffered saline pH7. 2
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Flow Cytometry:
Use 1ug to label 106 cells in 100ul. Suggested
Dilution:
Flow Cytometry - 1ug/ml - 10ug/mlImmunohistology - Frozen - 1ug/ml - 10ug/mlELISA - 1ug/mlWestern Blotting - 1ug/ml
Function:
Receptor for interferon gamma. Two receptors bind one interferon gamma dimer.
Subunit:
Monomer.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Ptm:
Phosphorylated at Ser/Thr residues.
Polymorphism:
A genetic variation in the IFNGR1 gene is associated with susceptibility to Helicobacter pylori infection [MIM:600263].
Disease:
Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood whereas others develop later in life disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive autosomal dominant or X-linked inheritance.
Similarity:
Belongs to the type II cytokine receptor family.
Similarity:
Contains 2 fibronectin type-III domains.
Similarity:
Contains 2 Ig-like C2-type (immunoglobulin-like) domains. 1. Entrican. G. et al. (2002) Gamma interferon fails to induce expression of indoleamine 2. 3-dioxygenase and does not control the growth of Chlamydophila abortus in BeWo trophoblast cells.
Amount: 0.025 mg
Available: In stock
Listprice: €177.85
Discount: -10.0%
Price: €160.07
You save: €17.79
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