CD104


Manufacturer	GENWAY
Category	Oncology Antibodies Flow Cytometry Primary Antibodies By Organ Renal Cancer
Type	Antibody
Specific against	other
Clone	450-9D
Applications	FC
Amount	0.025 mg
Item no.	20-783-310098
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-DF5C70
Specificity:	CD104NCBI
Gene ID:	3691
Specificity:	CD104
Clone:	450-9D
Immunogen:	Purified a6b4 integrin from A431 cells
Fusion Partner:	Spleen cells from immunised BALB/c mice were fused with cells of the mouse Sp2/0 myeloma cell line.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - Neat - 1/10
Function:	Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells.
Subunit:	Heterodimer of an alpha and a beta subunit. Beta-4 associates with alpha-6.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis lung duodenum heart spleen and stomach.
Domain:	The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230.
Disease:	Defects in ITGB4 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive frequently lethal epidermolysis bullosa with variable involvement of skin nails mucosa and with variable effects on the digestive system. It is characterized by mucocutaneous fragility aplasia cutis congenita and gastrointestinal atresia which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
Disease:	Defects in ITGB4 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]. GABEB is a non-lethal adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin associated with hair and tooth abnormalities.
Similarity:	Belongs to the integrin beta chain family.
Similarity:	Contains 1 Calx-beta domain.
Similarity:	Contains 4 fibronectin type-III domains.
Similarity:	Contains 1 VWFA domain. 1. Kennel. S. J. et al. (1990) Second generation monoclonal antibodies to the human integrin a6b4.

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Amount: 0.025 mg

available

Delivery expected until 5/9/2024