CD182


Manufacturer	GENWAY
Category	Neuroscience Neuroinflammation Antibodies Flow Cytometry Primary Antibodies
Type	Antibody
Specific against	other
Clone	HC2
Applications	FC
Amount	25 TESTS
Item no.	20-783-310099
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-CE2C7F
Specificity:	CD182NCBI
Gene ID:	3579
Specificity:	CD182
Clone:	HC2
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum Albumin Reconstitution: Reconstitute in 0. 25 ml disilled waterSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells or 100ul whole bloodSuggested
Dilution:	Flow Cytometry - Neat
Function:	Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3 GRO/MGSA and NAP-2.
Subcellular Location:	Cell membrane; Multi-pass membrane protein.
Ptm:	Phosphorylated upon ligand binding; which is required for desensitization.
Similarity:	Belongs to the G-protein coupled receptor 1 family [view classification]. 1. Petering. H. et al. (1999) The Biologic Role of Interleukin-8: Functional Analysis and Expression of CXCR1 and CXCR2 on Human Eosinophils. 2. Zahn. S. et al. (1997) Chemoattractant receptors for interleukin-8 and C5a: expression on peripheral blood leukocytes and differential regulation on HL-60 and AML-193 cells by vitamin D3 and all-trans retinoic acid.

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Amount: 25 TESTS

available

Delivery expected until 5/30/2024