G-CSF RECEPTOR

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone LMM775
Applications FC
Amount 25 TESTS
ArtNr 20-783-310109
Available
Genway ID:
GWB-49C305
Specificity:
G-CSF RECEPTORNCBI
Gene ID:
1441
Specificity:
G-CSF RECEPTOR
Clone:
LMM775
Preparation:
Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium Azide1%Bovine Serum Albumin
Reconstitution: Reconstitute in 0. 25 ml disilled waterSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood. Suggested
Dilution:
Flow Cytometry - Neat
Function:
Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.
Subunit:
Homodimer. The dimeric receptor binds two CSF3 molecules.
Subcellular Location:
Isoform 2: Secreted (Probable).
Subcellular Location:
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity:
One or several isoforms have been found in myelogenous leukemia cell line KG-1 leukemia U937 cell line in bone marrow cells placenta and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U937 cells. Isoform GSCFR-3 is highly expressed in placenta.
Domain:
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
Domain:
The box 1 motif is required for JAK interaction and/or activation.
Disease:
Defects in CSF3R may be a cause of severe congenital neutropenia (SCN) in some patients.
Similarity:
Belongs to the type I cytokine receptor family. Type 2 subfamily.
Similarity:
Contains 5 fibronectin type-III domains.
Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain. 1. Nicholson. S. E. et al. (1994) Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation.
Amount: 25 TESTS
Available: In stock
Listprice: €212.88
Discount: -10.0%
Price: €191.59
You save: €21.29
lieferbar

Get an offer

Technische Fragen zu diesem Produkt?


Salesmanager: Arne Pelz

Email: sales@hoelzel.de

Close