Comparison

G-CSF RECEPTOR

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone LMM775
Applications FC
Amount 25 TESTS
Item no. 20-783-310109
eClass 6.1 32160702
eClass 9.0 32160702
Available
Genway ID:
GWB-49C305
Specificity:
G-CSF RECEPTORNCBI
Gene ID:
1441
Specificity:
G-CSF RECEPTOR
Clone:
LMM775
Preparation:
Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium Azide1%Bovine Serum Albumin
Reconstitution: Reconstitute in 0. 25 ml disilled waterSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood. Suggested
Dilution:
Flow Cytometry - Neat
Function:
Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.
Subunit:
Homodimer. The dimeric receptor binds two CSF3 molecules.
Subcellular Location:
Isoform 2: Secreted (Probable).
Subcellular Location:
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity:
One or several isoforms have been found in myelogenous leukemia cell line KG-1 leukemia U937 cell line in bone marrow cells placenta and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U937 cells. Isoform GSCFR-3 is highly expressed in placenta.
Domain:
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
Domain:
The box 1 motif is required for JAK interaction and/or activation.
Disease:
Defects in CSF3R may be a cause of severe congenital neutropenia (SCN) in some patients.
Similarity:
Belongs to the type I cytokine receptor family. Type 2 subfamily.
Similarity:
Contains 5 fibronectin type-III domains.
Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain. 1. Nicholson. S. E. et al. (1994) Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 25 TESTS
Available: In stock
available

Delivery expected until 4/25/2024 

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