Manufacturer |
GENWAY
|
Category |
|
Type |
Antibody |
Specific against |
other |
Clone |
LMM775 |
Applications |
FC |
Amount |
25 TESTS |
Item no. |
20-783-310109 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Genway ID: |
GWB-49C305 |
Specificity: |
G-CSF RECEPTORNCBI |
Gene ID: |
1441 |
Specificity: |
G-CSF RECEPTOR |
Clone: |
LMM775 |
Preparation: |
Purified IgG prepared by affinity chromatography on Protein A |
Buffer Solution: |
Phosphate buffered saline pH7. 4 |
|
Preservative Stabilisers: |
| 0. 09%Sodium Azide1%Bovine Serum Albumin Reconstitution: Reconstitute in 0. 25 ml disilled waterSuggested |
Flow Cytometry: |
Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood. Suggested |
Dilution: |
Flow Cytometry - Neat |
Function: |
Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface. |
Subunit: |
Homodimer. The dimeric receptor binds two CSF3 molecules. |
Subcellular Location: |
Isoform 2: Secreted (Probable). |
Subcellular Location: |
Cell membrane; Single-pass type I membrane protein. |
Tissue Specificity: |
One or several isoforms have been found in myelogenous leukemia cell line KG-1 leukemia U937 cell line in bone marrow cells placenta and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U937 cells. Isoform GSCFR-3 is highly expressed in placenta. |
Domain: |
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. |
Domain: |
The box 1 motif is required for JAK interaction and/or activation. |
Disease: |
Defects in CSF3R may be a cause of severe congenital neutropenia (SCN) in some patients. |
Similarity: |
Belongs to the type I cytokine receptor family. Type 2 subfamily. |
Similarity: |
Contains 5 fibronectin type-III domains. |
Similarity: |
Contains 1 Ig-like C2-type (immunoglobulin-like) domain. 1. Nicholson. S. E. et al. (1994) Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation. |
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