Antibodies

INTEGRIN ALPHA 9 BETA 1

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against other
Clone Y9A2
Applications FC, IP
Amount 0.025 mg
ArtNr 20-783-310118
Available
Genway ID:
GWB-F161F0
Specificity:
INTEGRIN ALPHA 9 BETA 1NCBI
Gene ID:
3680
Specificity:
INTEGRIN ALPHA 9 BETA 1
Clone:
Y9A2
Immunogen:
alpha9 integrin transfected lambda cells.
Fusion Partner:
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106cells in 100ul.
Function:
Integrin alpha-9/beta-1 is a receptor for VCAM1 cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.
Subunit:
Heterodimer of an alpha and a beta subunit. Alpha-9 associates with beta-1.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
In airway epithelium in the basal layer of squamous epithelium and in smooth muscle skeletal muscle and hepatocytes. Abundantly expressed in fetal lung and lung cancers.
Induction:
Up-regulated in small cell lung cancers (SCLC).
Similarity:
Belongs to the integrin alpha chain family.
Similarity:
Contains 7 FG-GAP repeats. 1. Wang. A. et al. (1996) Differential regulation of airway epithelial integrins by growth factors. 2. Smith. L. L. et al. (1996) Osteopontin N-terminal domain contains a cryptic adhesive sequence recognised by alpha9 beta1 integrin. 3. Yokosaki. Y. et al. (1996) Differential effects of the integrins alpha9 beta1. alphaV/beta3 and alphaV beta6 on cell proliferative responses to tenascin. J. Biol. Chem. 271: 24144-24150.
Amount: 0.025 mg
Available: In stock
Listprice: €152.38
Price: €152.38
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