CD40


Manufacturer	GENWAY
Category	Oncology Antibodies Flow Cytometry Immunohistochemistry Immunoprecipitation Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Specific against	other
Clone	LOB7/6
Applications	FC, IP, IHC
Amount	0.025 mg
Item no.	20-783-310121
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-C901FE
Specificity:	CD40NCBI
Gene ID:	958
Specificity:	CD40
Clone:	LOB7/6
Fusion Partner:	Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
Immunohistology:	This product requires protein digestion pre-treatment of paraffin embedded sections prior to staining eg. pronase or trypsin. Histology: Human Tonsil
Preparation:	Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution:	Tris buffered saline
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - 20ug/mlImmunohistology - Frozen - 1ug/ml - 10ug/mlImmunohistology - Paraffin - 1ug/ml - 10ug/ml
Function:	Receptor for TNFSF5/CD40LG.
Subunit:	Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1 TRAF2 TRAF3 TRAF5 and TRAF6.
Subcellular Location:	Isoform I: Cell membrane; Single-pass type I membrane protein.
Subcellular Location:	Isoform II: Secreted.
Tissue Specificity:	B-cells and in primary carcinomas.
Disease:	Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3) [MIM:606843]. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching one of the final differentiation steps in the humoral immune system an inability to mount an antibody-specific immune response and a lack of germinal center formation.
Similarity:	Contains 4 TNFR-Cys repeats. 1. Quadbeck. B. et al. (2002) Maturation of thyroidal dendritic cells in Graves Disease. 2. Kirsch. B. M. et al . (2005) The active metabolite of leflunomide. A77 1726. interferes with dendritic cell function. Arthritis Res. Ther. 3. Cheadle. E. et al. (2003) Mycobacterium bovis bacillus Calmette-Guerin-infected dendritic cells potently activate autologous T cells via a B7 and interleukin-12-dependent mechanism. Immunology.

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Amount: 0.025 mg

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Delivery expected until 5/9/2024