Antibodies

CD340

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against other
Clone ICR55
Applications WB, IP, IHC
Amount 0.025 mg
ArtNr 20-783-310158
Available
Genway ID:
GWB-AED1BC
Specificity:
CD340NCBI
Gene ID:
2064
Specificity:
CD340
Clone:
ICR55
Preparation:
Purified IgG prepared by ion exchange chromatography from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline
Preservative Stabilisers:
0. 02%Sodium Azide
Function:
Essential component of a neuregulin-receptor complex although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF TGF-alpha and amphiregulin.
Catalytic Activity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit:
Heterodimer with each of the other ERBB receptors (Potential). Interacts with PRKCABP and PLXNB1. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with MEMO when phosphorylated on Tyr-1248. Interacts with MUC1. Stimulation by heregulin (HRG) in breast cancer cell lines induces binding of MUC1 with gamma-catenin.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Ptm:
Ligand-binding increases phosphorylation on tyrosine residues (By similarity).
Polymorphism:
There are fours alleles due to the variations in positions 654 and 655. Allele B1 (Ile-654/Ile-655) has a frequency of 0. 782; allele B2 (Ile-654/Val-655) has a frequency of 0. 206; allele B3 (Val-654/Val-655) has a frequency of 0. 012.
Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Similarity:
Contains 1 protein kinase domain. 1. Styles. J. M. et al. (1990) Rat monoclonal antibodies to the external domain of the product of the c-erbB-2 proto-oncogene. 2. Dean. C. J. et al. (1993) Rat MAbs to the product of the c-erbB-2 proto-oncogene for diagnosis and therapy in breast cancer.
Amount: 0.025 mg
Available: In stock
Listprice: €152.38
Price: €152.38
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