Comparison

CD340

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone ICR55
Applications WB, IP, IHC
Amount 0.025 mg
Item no. 20-783-310158
eClass 6.1 32160702
eClass 9.0 32160702
Available
Genway ID:
GWB-AED1BC
Specificity:
CD340NCBI
Gene ID:
2064
Specificity:
CD340
Clone:
ICR55
Preparation:
Purified IgG prepared by ion exchange chromatography from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline
Preservative Stabilisers:
0. 02%Sodium Azide
Function:
Essential component of a neuregulin-receptor complex although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF TGF-alpha and amphiregulin.
Catalytic Activity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit:
Heterodimer with each of the other ERBB receptors (Potential). Interacts with PRKCABP and PLXNB1. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with MEMO when phosphorylated on Tyr-1248. Interacts with MUC1. Stimulation by heregulin (HRG) in breast cancer cell lines induces binding of MUC1 with gamma-catenin.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Ptm:
Ligand-binding increases phosphorylation on tyrosine residues (By similarity).
Polymorphism:
There are fours alleles due to the variations in positions 654 and 655. Allele B1 (Ile-654/Ile-655) has a frequency of 0. 782; allele B2 (Ile-654/Val-655) has a frequency of 0. 206; allele B3 (Val-654/Val-655) has a frequency of 0. 012.
Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Similarity:
Contains 1 protein kinase domain. 1. Styles. J. M. et al. (1990) Rat monoclonal antibodies to the external domain of the product of the c-erbB-2 proto-oncogene. 2. Dean. C. J. et al. (1993) Rat MAbs to the product of the c-erbB-2 proto-oncogene for diagnosis and therapy in breast cancer.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 0.025 mg
Available: In stock
available

Delivery expected until 4/25/2024 

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