CD79b


Manufacturer	GENWAY
Category	Oncology Antibodies Flow Cytometry Immunohistochemistry Immunoprecipitation Western Blot Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Specific against	other
Clone	HM79-11
Applications	WB, FC, IP, IHC
Amount	0.025 mg
Item no.	20-783-310159
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-CA3480
Specificity:	CD79bNCBI
Gene ID:	15985
Specificity:	CD79b
Clone:	HM79-11
Immunogen:	CD79 alpha/CD79 beta heterodimer purified from WEH1231 B cells.
Fusion Partner:	Spleen cells from immunised Armenian hamsters were fused with cell of the mouse X63-Ag8. 653 myeloma cell line NS1
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells or 100ul whole bloodSuggested
Dilution:	Flow Cytometry - 1:50 - 1:100
Function:	Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
Subunit:	Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains.
Subcellular Location:	Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts (By similarity).
Tissue Specificity:	B-cells.
Ptm:	Phosphorylated on tyrosine upon B-cell activation.
Similarity:	Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Similarity:	Contains 1 ITAM domain. 1. Koyana. M. et al. (1997) CD79 alpha/CD79 beta heterodimers are expressed on pro-B cell surfaces without associated mu heavy chain.

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Amount: 0.025 mg

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Delivery expected until 5/9/2024