CD34


Manufacturer	GENWAY
Category	Oncology Antibodies Flow Cytometry Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Specific against	other
Clone	MEC14. 7
Applications	FC
Amount	0.025 mg
Item no.	20-783-310163
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-48D743
Specificity:	CD34NCBI
Gene ID:	12490
Specificity:	CD34
Clone:	MEC14. 7
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Dilution:	Flow Cytometry - Neat
Function:	Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. Developmental Stage: On early hematopoietic progenitor cells.
Ptm:	Highly glycosylated.
Ptm:	Phosphorylated on serine residues by PKC.
Disease:	Abnormal CD34 expression in leukemogenesis.
Similarity:	Belongs to the CD34 family. 1. Garlanda. C. et al. (1997) Characterization of MEC14. 7. a new monoclonal antibody recognising mouse CD34: a useful reagent for identifying and characterizing blood vessels and haematopoietic precursors. 2. Winding. B. et al. (2002) Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice.

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Amount: 0.025 mg

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Delivery expected until 5/9/2024