CD117

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone 104D2
Applications FC
Amount 25 TESTS
ArtNr 20-783-310166
Available
Genway ID:
GWB-D34C7C
Specificity:
CD117NCBI
Gene ID:
3815
Specificity:
CD117
Clone:
104D2
Immunogen:
MOLM-1 megakaryocytic cell line.
Buffer Solution:
Phosphate buffered saline
Preservative Stabilisers:
0. 09%Sodium Azide0. 2%Bovine Serum AlbuminSuggested
Flow Cytometry:
Use 20 ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:
Flow Cytometry - Neat
Function:
This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K).
Catalytic Activity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit:
Interacts with APS. Interacts with MPDZ (via the tenth PDZ domain). Interacts with PTPRU.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Disease:
Defects in KIT are a cause of piebaldism [MIM:172800]. Piebaldism is an autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes.
Disease:
Defects in KIT are a cause of gastrointestinal stromal tumor (GIST) [MIM:606764].
Disease:
Defects in KIT have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).
Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Similarity:
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Similarity:
Contains 1 protein kinase domain. 1. Broudy. V. C. et al. (1998) Analysis of c-kit receptor dimerization by fluorescence resonance energy transfer. 2. Yoshino. N. et al. (2000) Upgrading of flow cytometric analysis for absolute counts. cytokines and other antigenic molecules of Cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies.
Amount: 25 TESTS
Available: In stock
Listprice: €228.62
Discount: -10.0%
Price: €205.76
You save: €22.86
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