CD161


Manufacturer	GENWAY
Category	Oncology Antibodies Flow Cytometry Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Specific against	other
Clone	B199. 2
Applications	FC
Amount	0.025 mg
Item no.	20-783-310176
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-7C9B01
Specificity:	CD161NCBI
Gene ID:	3820
Specificity:	CD161
Clone:	B199. 2
Fusion Partner:	Spleen cells from immunised BALB/c mice were fused with cells of the mouse P2X63. Ag8. 653 myeloma cell line.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - Nt - 1/10
Function:	Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1 3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Subunit:	Homodimer; disulfide-linked. Interacts with acid sphingomyelinase/SMPD1.
Subcellular Location:	Membrane; Single-pass type II membrane protein (Potential).
Tissue Specificity:	Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.
Induction:	By IL12 in NK cells.
Ptm:	N-glycosylated. Contains sialic acid residues.
Similarity:	Contains 1 C-type lectin domain. 1. Bennett. I. M. et al. (1996) Definition of natural killer NKR-PIA+/CD56-/CD16- functionally immature human NK cell subset that differentiates in vitro in the presence of interleukin 12. 2. Azzoni. L. et al. (1998) Differential transcriptional regulation of CD161 and a novel gene. 197/15a. by IL-2. IL-15. and IL-12 in NK and T cells.

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Amount: 0.025 mg

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Delivery expected until 5/9/2024