Manufacturer |
GENWAY
|
Category |
|
Type |
Antibody |
Specific against |
other |
Clone |
MEM-180 |
Applications |
FC |
Amount |
0.025 mg |
Item no. |
20-783-310188 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Genway ID: |
GWB-E5613B |
Specificity: |
CD97NCBI |
Gene ID: |
976 |
Specificity: |
CD97 |
Clone: |
MEM-180 |
Preparation: |
Purified IgG prepared by affinity chromatography on Protein G |
Buffer Solution: |
Phosphate buffered saline pH7. 4 |
|
Preservative Stabilisers: |
| 0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested |
Flow Cytometry: |
Use 10ul of the suggested working dilution to label 106 cells or 100ul whole bloodSuggested |
Dilution: |
Flow Cytometry - Neat - 1/10 |
Function: |
Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity). |
Subunit: |
Forms a heterodimer consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Interacts with complement decay-accelerating factor (DAF). The largest isoform (isoform 1) interacts with chondroitin sulfate. |
Subcellular Location: |
Cell membrane; Multi-pass membrane protein. |
Subcellular Location: |
CD97 antigen subunit alpha: Secreted extracellular space. |
Tissue Specificity: |
Broadly expressed found on most hematopoietic cells including activated lymphocytes monocytes macrophages dendritic cells and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid colorectal gastric esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompagnied by detectable levels of soluble CD97 in the synovial fluid. |
Induction: |
Rapid up-regulation during lymphocyte activation. |
Domain: |
The first two EGF domains mediate the interaction with DAF. A third tandemly arranged EGF domain is necessary for the structural integrity of the binding region. |
Domain: |
Binding to chondroitin sulfate is mediated by the fourth EGF domain. |
Ptm: |
Proteolytically cleaved into 2 subunits an extracellular alpha subunit and a seven-transmembrane subunit (By similarity). |
Similarity: |
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily [view classification]. |
Similarity: |
Contains 5 EGF-like domains. |
Similarity: |
Contains 1 GPS domain. 1. Steinert. M. et al. (2002) Expression and regulation of CD97 in colorectal carcinoma cell lines and tumour tissues. |
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