CD252


Manufacturer	GENWAY
Category	Oncology Antibodies Flow Cytometry Immunohistochemistry Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Specific against	other
Clone	OX-89
Applications	FC, IHC
Amount	0.025 mg
Item no.	20-783-310190
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-4022D7
Specificity:	CD252NCBI
Gene ID:	22164
Specificity:	CD252
Clone:	OX-89
Immunogen:	Rat CD4 and mouse CD134 ligand Chimaeric protein
Fusion Partner:	Spleen cells from immunised PVG rats were fused with cells of the NS1 myeloma cell line.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Function:	Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
Subunit:	Homotrimer (Probable).
Subcellular Location:	Membrane; Single-pass type II membrane protein.
Induction:	By human T-cell leukemia virus type I transactivator P40-TAX.
Disease:	Genetic variation in TNFSF4 influences susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin joints kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Similarity:	Belongs to the tumor necrosis factor family. 1. Malstrom. V. et al (2001) CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice.

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Amount: 0.025 mg

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Delivery expected until 5/30/2024