CD115


Manufacturer	GENWAY
Category	Oncology Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Myeloma Melanoma Flow Cytometry Primary Antibodies By Organ Bone Cancer
Type	Antibody
Specific against	other
Clone	604B5 2E11
Applications	FC
Amount	0.025 mg
Item no.	20-783-310191
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-7B72EE
Specificity:	CD115NCBI
Gene ID:	12978
Specificity:	CD115
Clone:	604B5 2E11
Immunogen:	Raw 264 cells
Fusion Partner:	Spleen cells from immunised Sprague Dawley rats were fused with cells of the P3-653 myeloma cell line.
Preparation:	Purified IgG prepared by ion exchange chromatography
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - 1/25 - 1/50
Function:	Protein tyrosine-kinase transmembrane receptor for CSF1 and IL34.
Catalytic Activity:	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit:	Interacts with INPPL1/SHIP2 and THOC5 (By similarity).
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Expressed in bone marrow and in differentiated blood mononuclear cells.
Similarity:	Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Similarity:	Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Similarity:	Contains 1 protein kinase domain. 1. Shadduck. R. K. et al. (1996) Paradoxical stimulation of normal and leukemic rat hematopoiesis by monoclonal antibody to CSF-I receptor. 2. Gilmore. G. L. et al. (1995) Inhibition of day-12 spleen colony-forming units by a monoclonal antibody to the murine macrophage/monocyte colony-stimulating factor receptor. 3. MacDonald. K. P. A. et al. (2005) The colony stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion.

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Amount: 0.025 mg

available

Delivery expected until 5/30/2024