CD49c


Manufacturer	GENWAY
Category	Oncology Neuroscience Neural Adhesion Molecules Antibodies Flow Cytometry Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Specific against	other
Clone	17C6
Applications	FC
Amount	0.025 mg
Item no.	20-783-310201
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-E85B5E
Specificity:	CD49cNCBI
Gene ID:	3675
Specificity:	CD49c
Clone:	17C6
Immunogen:	CD49c transfected cell line
Fusion Partner:	Cells from immunised Balb/c mice were fused with cells of the NS2 mouse myeloma cell line.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Function:	Integrin alpha-3/beta-1 is a receptor for fibronectin laminin collagen epiligrin thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
Subunit:	Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Isoform alpha-3A is widely expressed. Isoform alpha-3B is expressed in brain and heart. In brain both isoforms are exclusively expressed on vascular smooth muscle cells whereas in heart isoform alpha-3A is strongly expressed on vascular smooth muscle cells isoform alpha-3B is detected only on endothelial vein cells.
Ptm:	Isoform alpha-3A but not isoform alpha-3B is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation. Isoform alpha-3A is phosphorylated on Tyr-1051.
Similarity:	Belongs to the integrin alpha chain family.
Similarity:	Contains 7 FG-GAP repeats.

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Amount: 0.025 mg

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Delivery expected until 5/30/2024