Antibodies

CD4

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone 700000000000
Applications FC
Amount 25 TESTS
ArtNr 20-783-310236
Available
Genway ID:
GWB-C9658F
Specificity:
CD4NCBI
Gene ID:
920
Specificity:
CD4
Clone:
700000000000000
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 08%Sodium Azide0. 2%Bovine Serum AlbuminSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood. Suggested
Dilution:
Flow Cytometry - Neat
Function:
Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Subunit:
Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with and sequesters CD4 in the endoplasmic reticulum.
Ptm:
Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Miscellaneous:
Primary receptor for HIV-1.
Similarity:
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain. 1. Sopper. S. et al. (1997) Lymphocyte subsets and expression of differentiation markers in blood
Amount: 25 TESTS
Available: In stock
Listprice: €228.62
Discount: -10.0%
Price: €205.76
You save: €22.86
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