CD4


Manufacturer	GENWAY
Category	Antibodies Flow Cytometry Primary Antibodies
Type	Antibody
Specific against	other
Clone	700000000000
Applications	FC
Amount	25 TESTS
Item no.	20-783-310236
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-C9658F
Specificity:	CD4NCBI
Gene ID:	920
Specificity:	CD4
Clone:	700000000000000
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 08%Sodium Azide0. 2%Bovine Serum AlbuminSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood. Suggested
Dilution:	Flow Cytometry - Neat
Function:	Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Subunit:	Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins.
Subcellular Location:	Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with and sequesters CD4 in the endoplasmic reticulum.
Ptm:	Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Miscellaneous:	Primary receptor for HIV-1.
Similarity:	Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Similarity:	Contains 1 Ig-like V-type (immunoglobulin-like) domain. 1. Sopper. S. et al. (1997) Lymphocyte subsets and expression of differentiation markers in blood

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 25 TESTS

available

Delivery expected until 5/30/2024