Antibodies

CD120a

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone HM104
Applications FC
Amount 25 TESTS
ArtNr 20-783-310238
Available
Genway ID:
GWB-A0301F
Specificity:
CD120aNCBI
Gene ID:
21937
Specificity:
CD120a
Clone:
HM104
Preparation:
Purified IgG prepared by ion exchange chromatography.
Buffer Solution:
Phosphate buffered saline
Preservative Stabilisers:
0. 02%Sodium Azide0. 5%Bovine Serum AlbuminSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Dilution:
Flow Cytometry - Neat
Function:
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Subunit:
Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS RIPK1 and possibly FADD are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades apoptosis and NF-kappa-B signaling. Interacts with BAG4 BRE FEM1B GRB2 SQSTM1 and TRPC4AP. Interacts with HCV core protein.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Secreted.
Domain:
The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
Domain:
Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP (By similarity).
Ptm:
The soluble form is produced from the membrane form by proteolytic processing.
Disease:
Defects in TNFRSF1A are the cause of familial hibernian fever (FHF) [MIM:142680]; also known as tumor necrosis factor receptor-associated periodic syndrome (TRAPS). FHF is a hereditary periodic fever syndrome characterized by recurrent fever abdominal pain localized tender skin lesions and myalgia. Reactive amyloidosis is the main complication and occurs in 25% of cases.
Similarity:
Contains 1 death domain.
Similarity:
Contains 4 TNFR-Cys repeats.
Amount: 25 TESTS
Available: In stock
Listprice: €468.97
Discount: -10.0%
Price: €422.07
You save: €46.90
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