CD49b


Manufacturer	GENWAY
Category	Oncology Neuroscience Neural Adhesion Molecules Antibodies Flow Cytometry Primary Antibodies By Organ Bladder Cancer
Type	Antibody
Specific against	other
Clone	DX5
Applications	FC
Amount	0.025 mg
Item no.	20-783-310248
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-522DA0
Specificity:	CD49bNCBI
Gene ID:	16398
Specificity:	CD49b
Clone:	DX5
Immunogen:	RIL-2 propogated NK1. 1+ cells from C57BL/6 mice.
Fusion Partner:	Mouse SP2/0 myeloma line.
Buffer Solution:	Borate buffered saline pH8. 0
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Function:	Integrin alpha-2/beta-1 is a receptor for laminin collagen collagen C-propeptides fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens modulation of collagen and collagenase gene expression force generation and organization of newly synthesized extracellular matrix.
Subunit:	Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Domain:	The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Polymorphism:	Position 534 is associated with platelet-specific alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534 and HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). The Lys-534-Glu polymorphism may play a role in coronary artery disease (CAD).
Similarity:	Belongs to the integrin alpha chain family.
Similarity:	Contains 7 FG-GAP repeats.
Similarity:	Contains 1 VWFA domain. 1. Arase. H. et al. (2001) Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin. very late antigen-2)

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Amount: 0.025 mg

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Delivery expected until 5/9/2024