Antibodies

CD49b

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against other
Clone DX5
Applications FC
Amount 0.025 mg
ArtNr 20-783-310248
Available
Genway ID:
GWB-522DA0
Specificity:
CD49bNCBI
Gene ID:
16398
Specificity:
CD49b
Clone:
DX5
Immunogen:
RIL-2 propogated NK1. 1+ cells from C57BL/6 mice.
Fusion Partner:
Mouse SP2/0 myeloma line.
Buffer Solution:
Borate buffered saline pH8. 0
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Function:
Integrin alpha-2/beta-1 is a receptor for laminin collagen collagen C-propeptides fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens modulation of collagen and collagenase gene expression force generation and organization of newly synthesized extracellular matrix.
Subunit:
Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Domain:
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Polymorphism:
Position 534 is associated with platelet-specific alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534 and HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). The Lys-534-Glu polymorphism may play a role in coronary artery disease (CAD).
Similarity:
Belongs to the integrin alpha chain family.
Similarity:
Contains 7 FG-GAP repeats.
Similarity:
Contains 1 VWFA domain. 1. Arase. H. et al. (2001) Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin. very late antigen-2)
Amount: 0.025 mg
Available: In stock
Listprice: €152.38
Price: €152.38
lieferbar

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