Antibodies

CD180

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against other
Clone RP/14
Applications FC
Amount 0.025 mg
ArtNr 20-783-310253
Available
Genway ID:
GWB-2FF891
Specificity:
CD180NCBI
Gene ID:
17079
Specificity:
CD180
Clone:
RP/14
Buffer Solution:
Phosphate buffered saline
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Function:
May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).
Subunit:
Binds to MD-1.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity:
Expressed mainly on mature peripherical B cells. Detected in spleen lymph node and appendix. Not detected in pre-B and -T cells.
Disease:
Decreased expression of LY64 has been shown in systemic lupus erythematosus (SLE). The loss of LY64 is associated with B-cell activation and increased disease activity in SLE patients.
Similarity:
Belongs to the Toll-like receptor family.
Similarity:
Contains 17 LRR (leucine-rich) repeats. 1. Nagai. Y. et al. (2002) Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide. 2. Miyake. K. et al. (1998) Mouse MD-1. a molecule that is physically associated with RP105 and positively regulates its expression.
Amount: 0.025 mg
Available: In stock
Listprice: €212.88
Price: €212.88
lieferbar

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