Antibodies

CD180

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against other
Clone MHR73
Applications FC, IP, IHC
Amount 0.025 mg
ArtNr 20-783-310254
Available
Genway ID:
GWB-9F2F9C
Specificity:
CD180NCBI
Gene ID:
4064
Specificity:
CD180
Clone:
MHR73
Immunogen:
M12HRP cell line.
Fusion Partner:
Spleen cells from immunised Balb/c mice were fused with cells of the SP2/0 myeloma cell line. Histology: Tonsil
Buffer Solution:
Phosphate buffered saline
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:
Flow Cytometry - 1/50 - 1/100
Function:
May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).
Subunit:
Binds to MD-1.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity:
Expressed mainly on mature peripherical B cells. Detected in spleen lymph node and appendix. Not detected in pre-B and -T cells.
Disease:
Decreased expression of LY64 has been shown in systemic lupus erythematosus (SLE). The loss of LY64 is associated with B-cell activation and increased disease activity in SLE patients.
Similarity:
Belongs to the Toll-like receptor family.
Similarity:
Contains 17 LRR (leucine-rich) repeats. 1. Miura. Y. et al. (1998) RP105 is associated with MD-1 and transmits an activation signal in human B cells.
Amount: 0.025 mg
Available: In stock
Listprice: €258.32
Price: €258.32
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