CD14

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone MEM-18
Applications WB, FC, IP, ELISA
Amount 0.025 mg
ArtNr 20-783-310268
Available
Genway ID:
GWB-265CE4
Specificity:
CD14NCBI
Gene ID:
929
Specificity:
CD14
Clone:
MEM-18
Fusion Partner:
Spleen cells from mice immunised BALB/c mice were fused with cells from the NS1-Ag4/1 mouse myeloma line.
Preparation:
Purified IgG prepared by DEAE - Chromatogaphy
Buffer Solution:
Phosphate buffered saline
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:
Western Blotting - Non-reducing conditions
Function:
Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88 TIRAP and TRAF6 leading to NF-kappa-B activation cytokine secretion and the inflammatory response. Up-regulates cell surface molecules including adhesion molecules.
Subunit:
Belongs to the lipopolysaccharide (LPS) receptor a multi-protein complex containing at least CD14 MD-2 and TLR4.
Subcellular Location:
Cell membrane; Lipid-anchor GPI-anchor.
Tissue Specificity:
Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
Similarity:
Contains 11 LRR (leucine-rich) repeats. 1. Pltz. S. G. et al. (2001) The interaction of human peripheral blood eosinophils with bacterial lipopolysacchride is CD14 dependent. Blood. 97: 235 - 241. 2. Prager. E. et al. (2001) Induction of Hyporesponsiveness and Impaired T lymphocyte activation by the CD31 receptor: ligand pathway in T cells. 3. Thacker. E. et al. (2001) Summary of workshop findings for porcine myelomonocytic markers.
Amount: 0.025 mg
Available: In stock
Listprice: €152.38
Discount: -10.0%
Price: €137.14
You save: €15.24
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