CD206


Manufacturer	GENWAY
Category	Oncology Neuroscience Neural Lineage Markers Antibodies Flow Cytometry Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Specific against	other
Clone	MR5D3
Applications	FC
Amount	0.025 mg
Item no.	20-783-310286
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-72469F
Specificity:	CD206NCBI
Gene ID:	17533
Specificity:	CD206
Clone:	MR5D3
Immunogen:	Chimaeric CRD4-7-Fc protein.
Fusion Partner:	Spleen cells from immunised Fischer rats were fused with cells of the Y3 myeloma cell line.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Dilution:	Flow Cytometry - Neat - 1/10
Function:	Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria fungi and other pathogens.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Miscellaneous:	CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4 5 and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.
Similarity:	Contains 8 C-type lectin domains.
Similarity:	Contains 1 fibronectin type-II domain.
Similarity:	Contains 1 ricin B-type lectin domain. 1. Martinez-Pomares. L. et al. (2003) Analysis of mannose receptor regulation by IL-4. IL-10 and proteolytic processing using novel monoclonal antibodies. 2. Zamze. S. et al. (2002) Recognition of bacterial capsular polysaccharides and lipopolysaccharides by the macrophage mannose receptor.

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Amount: 0.025 mg

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Delivery expected until 5/9/2024